Laser Optofluidics in Fighting Multiple Drug Resistance

Application of Optically Modified Medicines in Fighting Pseudotumours

Author(s): Ruxandra Pirvulescu, Tatiana Tozar, Alexandru Stoicu and Mihail Lucian Pascu

Pp: 366-406 (41)

DOI: 10.2174/9781681084985117010016

* (Excluding Mailing and Handling)


Results are shown about the applications of medicines modified by exposure to optical radiation on pseudotumours indusced in rabbit eyes. These consist, first, in characterising modifications produced on medicines by exposing them to optical/laser radiation. Selected medicines are (i) cytostatics: methotrexate, 5-fluorouracil, (ii) benzopyridine derivatives: BG 204, BG 1120, (iii) phenothiazines: chlopromazine. They were used as solutions either in water or in natural saline. The anti-tumour properties of resulted solutions are measured after applying them on pseudotumours induced in rabbit eyes by Schmidt-Erfurth method. The use of methotrexate on pseudotumours has shown that eye conjunctive and neovascularisation disappear after 1-2 treatments which consists in exposure of eye injected with unirradiated methotrexate solution to cw Hg lamp radiation. Even if the use of methotrexate fastens the recovery, one should avoid direct exposure of eye to UV-Vis radiation. 5-fluorouracil was exposed to nitrogen pulsed laser beam which was sent to the eye already impregnated with cytostatics. Eye conjunctive and neovascularisation disappeared after 1-2 treatments, recommending 5-fluorouracil to cure such pseudotumours by combining its action with that of 337.1 nm laser. BG 1120 was used only exposed to cw Xe lamp incoherent radiation, without irradiating the eyes impregnated with solutions of it. BG 1120 modified by exposure to optical radiation leads to faster decrease of inflammations associated with pseudotumours and of neovascularisation of conjunctive tissue. For chlorpromazine, the most efficient in the recovery of a pseudotumour tissue is the sample irradiated 20 min, at 10 mg/ml concentration in water.

Keywords: Absorption spectroscopy, Benzopyridine derivatives, Chlorpromazine, Cytostatics, 5-fluorouracil, FTIR, Hg-lamp, Laser inducedfluorescence, Laser spectroscopy , Malignant tumours, Methotrexate, Multiple drug resistance, Nitrogen pulsed laser, Ophthalmology, Phenothiazine derivatives, Photochemistry, Pseudotumours, Solid state laser, Xenon lamp.

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