Results are shown about the applications of medicines modified by exposure
to optical radiation on pseudotumours indusced in rabbit eyes. These consist, first, in
characterising modifications produced on medicines by exposing them to optical/laser
radiation. Selected medicines are (i) cytostatics: methotrexate, 5-fluorouracil,
(ii) benzopyridine derivatives: BG 204, BG 1120, (iii) phenothiazines: chlopromazine.
They were used as solutions either in water or in natural saline. The anti-tumour
properties of resulted solutions are measured after applying them on pseudotumours
induced in rabbit eyes by Schmidt-Erfurth method. The use of methotrexate on
pseudotumours has shown that eye conjunctive and neovascularisation disappear after
1-2 treatments which consists in exposure of eye injected with unirradiated
methotrexate solution to cw Hg lamp radiation. Even if the use of methotrexate fastens
the recovery, one should avoid direct exposure of eye to UV-Vis radiation.
5-fluorouracil was exposed to nitrogen pulsed laser beam which was sent to the eye
already impregnated with cytostatics. Eye conjunctive and neovascularisation
disappeared after 1-2 treatments, recommending 5-fluorouracil to cure such
pseudotumours by combining its action with that of 337.1 nm laser. BG 1120 was used
only exposed to cw Xe lamp incoherent radiation, without irradiating the eyes
impregnated with solutions of it. BG 1120 modified by exposure to optical radiation
leads to faster decrease of inflammations associated with pseudotumours and of
neovascularisation of conjunctive tissue. For chlorpromazine, the most efficient in the
recovery of a pseudotumour tissue is the sample irradiated 20 min, at 10 mg/ml
concentration in water.
Keywords: Absorption spectroscopy, Benzopyridine derivatives,
Chlorpromazine, Cytostatics, 5-fluorouracil, FTIR, Hg-lamp, Laser
inducedfluorescence, Laser spectroscopy , Malignant tumours, Methotrexate, Multiple drug resistance, Nitrogen pulsed laser, Ophthalmology, Phenothiazine
derivatives, Photochemistry, Pseudotumours, Solid state laser, Xenon lamp.
