The chapter presents a synthesis of results obtained on resonant interaction
of laser radiation with medicines, in bulk, such as: cytostatics (methotrexate,
5-fluorouracil), phenothiazines (thioridazine, promethazine), quinazoline derivative
(BG 1188) and hydantoin derivative (SZ-2). The effect of laser radiation on the studied
samples is evaluated by analytical techniques out of which steady state absorption
spectroscopy, laser induced fluorescence and FTIR spectroscopy, phosphorescence of
generated photosensitised singlet oxygen and thin layer chromatography (TLC) used
for qualitative photoproducts evidencing are approached. The molecular structural
changes are suggested and the obtained photoproducts under laser exposure are
analysed by spectroscopic means. This kind of data is related to a new method to
combat multiple drug resistance acquired by microorganisms and tumours which
develop new chemicals with bactericide or antitumour effects by exposing existing
medicines that have low effects or are un-efficient, to laser beams.
Keywords: Absorption spectroscopy, Cytostatics, 5-fluorouracil, FTIR,
Hydantoin derivatives, Laser induced fluorescence, Laser photochemistry, Methotrexate,
Phenothiazine, Photosensitive medicines, Promethazine, Quinazoline
derivatives, Singlet oxygen phosphorescence, Thin layer chromatography,
Thioridazine.
