Precision measurements of surface tension and contact angle were
performed on some medicines from the phenothiazine class (chlorpromazine,
promethazine, and thioridazine) at different temperatures and concentrations in water,
using the pending drop and the sessile drop methods. A specialised system DSA 100
(Krüss) was used for these measurements. Precautions were taken for an optimal
acquisition of images (thermal isolation and heated windows of the chamber holding
the studied droplets). Contact angles either static or dynamic were determined. Density
measurements were also performed for the solutions. The same experiments were
performed on these solutions after UV laser irradiation. The obtained values were
discussed in comparison with the solvent behaviour and with the behaviour of other
drugs (of alizarin dye class) as well. The average values of the advancing and receding
angle, determined using a home developed program, are here presented for the first
time.
Keywords: Chlorpromazine, CPZ, Daunorubicin, Density measurement,
Doxorubicin, Drop interface, Dynamic contact angle, Laser irradiation, Nd:YAG
laser, Pendent drop, Polytetrafluoroethylene, PTFE, Promethazine, PMZ, Sessile
drop, Surface tension, Thioridazine, TZ, Ultrapure water, Vancomycin.