Introduction
This thematic issue aims to provide a comprehensive overview of the molecular mechanisms and protective strategies involved in neurological disorders, including stroke, Parkinson’s disease, Alzheimer’s disease, epilepsy, traumatic brain injury, encephalitis, and multiple sclerosis. The issue will focus on emerging insights into neuroinflammation, oxidative stress, mitochondrial dysfunction, autophagy, ferroptosis, and immune regulation, highlighting their roles in neuronal injury and repair. Contributions are encouraged from experimental, clinical, and bioinformatics perspectives to elucidate pathophysiological pathways and identify novel therapeutic targets. By integrating mechanistic discoveries with translational strategies, this issue seeks to advance the development of effective neuroprotective interventions and foster cross-disciplinary collaboration in the field of neurobiology and neurotherapeutics.
Keywords
Neurological Disorders, Neuroinflammation, Neuroprotection, Stroke, Parkinson’s Disease, Alzheimer’s Disease, Epilepsy, Translational Research.
Sub-topics
• Oxidative stress, neuroinflammation, and mitochondrial dysfunction in neurological disorders
• Autophagy, ferroptosis, and other regulated cell death pathways in neuronal injury and repair
• Glial activation, immune responses, and neuroimmune modulation in CNS diseases
• Molecular crosstalk between endoplasmic reticulum stress, mitochondrial quality control, and neuroprotection
• Translational neuroprotection: from molecular targets to therapeutic strategies in stroke, Parkinson’s disease, and Alzheimer’s disease
• Network pharmacology, bioinformatics, and systems biology in identifying novel neuroprotective mechanisms
• Experimental and clinical biomarkers for disease progression and therapeutic response in neurological disorders
• Emerging pharmacological and non-pharmacological interventions for CNS injury and regeneration
