Introduction
The field of drug discovery has witnessed tremendous progress, with an increasing number of novel bioactive compounds showing potential in the treatment of complex diseases. However, understanding the metabolism of these compounds, along with their pharmacokinetics and bioanalysis, remains a critical step in the drug development process. The way in which bioactive compounds are metabolized can significantly influence their efficacy, toxicity, and overall therapeutic potential. Moreover, bioanalytical techniques are vital in tracking these compounds within biological systems, ensuring the right therapeutic concentrations, and confirming their safety and effectiveness. This special issue seeks to explore recent advancements in drug discovery, focusing on the metabolic pathways of bioactive compounds and the role of bioanalysis in shaping their clinical success. The issue will highlight cutting-edge research that bridges pharmacology, toxicology, and analytical chemistry, bringing together experts from various disciplines to offer comprehensive insights into the drug discovery process.
Keywords
Bioactive compounds, Metabolism, Toxicity, Pharmacokinetic, Pharmacodynamics.
Sub-topics
- Metabolism of Bioactive compound(s)-Derived Bioactive: Enzymatic
pathways (Phase I/II), cytochrome P450's role, genetic influences on
the metabolism of plant compounds, metabolite ID/characterization (MS,
NMR).
- Pharmacokinetics/Bioavailability of Bioactive compound(s)-: ADME properties, delivery optimization for plant bioactives, food/disease/drug interactions specific to these compounds.
- Bioanalysis of Bioactive compound(s): Advances
in HPLC, UPLC, MS; novel methods for quantifying plant compounds and
their metabolites in biological matrices; integration of in vitro, in vivo, and clinical data.
- Modeling of Bioactive compound(s) Metabolism: Computational/in silico predictions, AI/machine learning applied to plant-derived compound pharmacokinetics and bioanalysis.
- Safety/Toxicology of Bioactive compound(s): Toxicity
mechanisms, ADR prediction via metabolic profiling, and strategies to
mitigate toxicity, particularly relevant to plant extracts and complex
mixtures.
