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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Venoms and Isolated Toxins from Snakes of Medical Impact in the Northeast Argentina: State of the Art. Potential Pharmacological Applications

Author(s): María Emilia Garcia Denegri, Soledad Bustillo, Claudia Carolina Gay, Andrea Van De Velde, Gabriela Gomez, Silvina Echeverría, María Del Carmen Gauna Pereira, Silvana Maruñak, Sandra Nuñez, Fabián Bogado, Matías Sanchez, Gladys Pamela Teibler, Luciano Fusco* and Laura Cristina Ana Leiva*

Volume 19, Issue 22, 2019

Page: [1962 - 1980] Pages: 19

DOI: 10.2174/1568026619666190725094851

Price: $65

Open Access Journals Promotions 2
Abstract

Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore, constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.

Keywords: Bothrops alternatus, Bothrops diporus, Crotalus durisus terrificus, Phospholipases A2, Serinoproteases, Metalloproteinases, Serine/thrombin-like proteinases, Crotoxin, Snake venom.

Graphical Abstract
[1]
Giraudo, A.; Arzamendia, V.; Bellini, G.; Bessa, C.; Calamante, C.; Cardozo, G.; Chiaraviglio, M.; Constanzo, M.; Etchepare, E.; Di Cola, V.; Di Pietro, D.; Kretzchmar, S.; Palomas, S.; Nenda, S.; Rivera, P.; Rodríguez, M.; Scrocchi, G.; Williams, J. Categorization of the conservation status of the Snakes of the Argentine Republic. Cuad. Herpetol., 2012, 26(Suppl. 1), 303-326.
[2]
Orduna, T.A.; Lloveras, S.C.; de Roodt, A.R.; Costa de Oliveira, V.; García, S.I.; Haas, A.I. Guide for prevention, diagnosis, treatment and epidemiological surveillance of office poisonings, portal of the ministry of health of the nation; National program for the prevention and control of poisoning, Buenos Aires. , 2014.
[3]
Giraudo, A.R. Diversity and natural history of snakes with health interest from northeastern Argentina In: The problem of office building in the northeast region of Argentina. An integrative scientific view: (Eds. Salomon, D.; Peichotto, M.E.), National institute of tropical medicine, Brussels, 2014, pp. 9-68.
[4]
Nori, J.; Carrasco, P.A.; Leynaud, G.C. Venomous snakes and climate change: ophidism as a dynamic problem. Clim. Change, 2014, 122(1-2), 67-80.
[http://dx.doi.org/10.1007/s10584-013-1019-6]
[5]
Gay, C.C.; Leiva, L.C.; Maruñak, S.; Teibler, P.; Acosta de Pérez, O. Proteolytic, edematogenic and myotoxic activities of a hemorrhagic metalloproteinase isolated from Bothrops alternatus venom. Toxicon, 2005, 46(5), 546-554.
[http://dx.doi.org/10.1016/j.toxicon.2005.06.019] [PMID: 16137735]
[6]
Maruñak, S.; Acosta, O. Mice plasma fibrinogen consumption by thrombin-like enzyme present in Crotalus durissus terrificus (rattlesnake) venom from the North-east region of Argentina. MEDICINA. Buenos Aires, 2004. 64, 509-517.
[PMID: 15637828]
[7]
Garcia Denegri, M.E.; Acosta, O.C.; Huancahuire-Vega, S.; Martins-de-Souza, D.; Marangoni, S.; Maruñak, S.L.; Teibler, G.P.; Leiva, L.C.; Ponce-Soto, L.A. Isolation and functional characterization of a new acidic PLA(2) Ba SpII RP4 of the Bothrops alternatus snake venom from Argentina. Toxicon, 2010, 56(1), 64-74.
[http://dx.doi.org/10.1016/j.toxicon.2010.02.031] [PMID: 20331996]
[8]
Rodríguez, J.P.; De Marzi, M.; Maruñak, S.; Malchiodi, E.L.; Leiva, L.C.; Acosta, O.C. Rabbits IgG antibodies against phospholipase A2 from Crotalus durissus terrificus venom neutralize the lethal activity. MEDICINA. Buenos Aires, 2006. 66(6), 512-516.
[PMID: 17240621]
[9]
Van de Velde, A.C.; Gay, C.C.; Moritz, M.N.O.; Dos Santos, P.K.; Bustillo, S.; Rodríguez, J.P.; Acosta, O.C.; Biscoglio, M.J.; Selistre-de-Araujo, H.S.; Leiva, L.C. Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom. Int. J. Biol. Macromol., 2018, 113, 205-211.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.02.063] [PMID: 29471097]
[10]
Giraudo, A.R.; Arzamendia, V.; Lopez, S.M.; Quaini, R.O.; Prieto, Y.; Leiva, L.A.; Regner, S.A.; Urban, J.M. Poisonous snakes of santa fe, Argentina: Knowledge about its natural history applied to the prevention of ophtism. FABICIB, 2008, 12, 69-89.
[http://dx.doi.org/10.14409/fabicib.v12i1.819]
[11]
Meneghel, M.D. Visceral anatomy and circulatory system of the Crotalidae of Uruguay. Master's thesis in biology, zoology option, Basic science development program, (PEDECIBA), Faculty of sciences, University of the republic, Montevideo, 1997. xii + 128 pp.
[12]
Gutiérrez, J.M.; Calvete, J.J.; Habib, A.G.; Harrison, R.A.; Williams, D.J.; Warrell, D.A. Snakebite envenoming. Nat. Rev. Dis. Primers, 2017, 3, 17063.
[http://dx.doi.org/10.1038/nrdp.2017.63] [PMID: 28905944]
[13]
Lanari, L.C.; Rosset, S.; González, M.E.; Liria, N.; de Roodt, A.R. A study on the venom of Bothrops alternatus Duméril, Bibron and Duméril, from different regions of Argentina. Toxicon, 2010, 55(8), 1415-1424.
[http://dx.doi.org/10.1016/j.toxicon.2010.01.015] [PMID: 20170669]
[14]
Acosta de Pérez, O.C.; Koscinczuk, P.; Teibler, P.; Sánchez Negrette, M.; Ruiz, R.; Maruñak, S.; Bogarín, G. Hemorrhagic and edematizing activities and histological alterations in plantar pad of the mouse induced by snake venoms of the Bothrops and Crotalus genera of Argentina. Toxicon, 1998, 36(8), 1165-1172.
[http://dx.doi.org/10.1016/S0041-0101(98)00007-5] [PMID: 9690783]
[15]
Teibler, P.; Acosta, O.; Leiva, L.; Ríos, E.; Maruñak, S.; Ruiz, R.; Resoagli, E.; Zeinsteger, P.; Pollitt, C. Characterization by optical and electron microscopy of venom and PLA2 induced foot lesions of bothrops genus snakes (yarana). InVet (B. Aires), 2002, 4(81), 83-92.
[16]
Gutiérrez, J.M.; Lomonte, B. Local tissue damage induced by Bothrops snake venoms. Rev. Mem. Inst. Butantan, 1989, 51(4), 211-223.
[17]
Gutiérrez, J.M.; Chaves, F. Proteolytic, hemorrhagic and myonecrotic effects of the Costa Rican snake venoms of the genus Bothrops, Crotalus and Lachesis. Toxicon, 1980, 18(3), 315-321.
[http://dx.doi.org/10.1016/0041-0101(80)90011-2] [PMID: 6994273]
[18]
Gutiérrez, J.M.; Ownby, C.L.; Odell, G.V. Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper. Exp. Mol. Pathol., 1984, 40(3), 367-379.
[http://dx.doi.org/10.1016/0014-4800(84)90054-6] [PMID: 6539250]
[19]
Queiroz, L.S.; Petta, C.A. Histopathological changes caused by venom of urutu snake (Bothrops alternatus) in mouse skeletal muscle. Rev. Inst. Med. Trop. São Paulo, 1984, 26(5), 247-253.
[http://dx.doi.org/10.1590/S0036-46651984000500004] [PMID: 6533749]
[20]
Echeverría, S.; Leiguez, E.; Guijas, C.; do Nascimento, N.G.; Acosta, O.; Teixeira, C.; Leiva, L.C.; Rodríguez, J.P. Evaluation of pro-inflammatory events induced by Bothrops alternatus snake venom. Chem. Biol. Interact., 2018, 281, 24-31.
[http://dx.doi.org/10.1016/j.cbi.2017.12.022] [PMID: 29248447]
[21]
Yamakawa, M. Nozaki, M., and Hokama, Z. Fractionation of Sakishima-habu (Trimeresurus elegans) venom and lethal, hemorrhagic and edema-forming activities of the fractions.Animal, plant and microbial toxins; Ohsaka, A.; Hayashi, K; Sawai, Y., Ed.; Plenum Press: New York, 1976, pp. 97-109.
[http://dx.doi.org/10.1007/978-1-4684-0886-7_10]
[22]
Acosta de Pérez, O.; Koscinczuk, P.; Gutiérrez, J.M. Hemorrhagic and coagulant activities of Bothrops alternatus venom from Argentina. Acta Bioquim. Clin. Latinoam., 1996, 30, 401-405.
[23]
Gay, C.; Maruñak, S.; Teibler, P.; Leiva, L.; Acosta, O. Effect of monospecific antibodies against baltergin in myotoxicity induced by Bothrops alternatus venom from northeast of Argentina. Role of metalloproteinases in muscle damage. Toxicon, 2013, 63, 104-111.
[http://dx.doi.org/10.1016/j.toxicon.2012.11.028] [PMID: 23246580]
[24]
Garcia Denegri, M.E.; Teibler, G.P.; Maruñak, S.L.; Hernández, D.R.; Acosta, O.C.; Leiva, L.C. Efficient muscle regeneration after highly haemorrhagic Bothrops alternatus venom injection. Toxicon, 2016, 122, 167-175.
[http://dx.doi.org/10.1016/j.toxicon.2016.10.005] [PMID: 27720976]
[25]
Echeverría, S.M.; Teibler, G.P.; Maruñak, S.L.; Lértora, W.J.; Leiva, L.C. Microscopic changes in lymph nodes of mice inoculated with venom from Bothrops alternatus. Rev. Vet., 2015, 26(2), 113-119.
[26]
Acosta de Pérez, O.; Koscinczuk, P.; Teibler, P.; Maruñak, S. Alterations in blood clotting induced by Bothrops alternatus venom (yarana large). Response to specific treatment. Acta Toxicol. Argent., 1996, 4, 28-30.
[27]
Acosta de Pérez, O.; Koscinczuk, P.; Sánchez Negrette, M.; Teibler, P.; Ruiz, R. Effects of Argentina’s Bothrops alternatus venom on muscle and different organs of mice. Acta Physiol. Pharmacol. Ther. Latinoam., 1996, 46, 97-102.
[28]
Ruiz de Torrent, R.M.; Leiva, L.C.; Acosta de Perez, O.C. Proteolytic effect of snake venoms of the genus Bothrops (yarara) of Argentina and its neutralization by a bivalent antivenom. Acta Toxicol. Argent., 2001, 9(1), 9-12.
[29]
De Pérez, A.; Castro, C.O.; Dir, J.A. Biochemical and pharmacological characterization of Bothrops alternatus venom., Buenos Aires’ University; Faculty of Veterinary Sciences: Buenos Aires, 1999.
[30]
Gay, C.C.; Maruñak, S.L.; Teibler, P.; Ruiz, R.; Acosta de Pérez, O.C.; Leiva, L.C. Systemic alterations induced by a Bothrops alternatus hemorrhagic metalloproteinase (baltergin) in mice. Toxicon, 2009, 53(1), 53-59.
[http://dx.doi.org/10.1016/j.toxicon.2008.10.010] [PMID: 18983866]
[31]
Sanchez, E.F.; Freitas, T.V.; Ferreira-Alves, D.L.; Velarde, D.T.; Diniz, M.R.; Cordeiro, M.N.; Agostini-Cotta, G.; Diniz, C.R. Biological activities of venoms from South American snakes. Toxicon, 1992, 30(1), 95-103.
[http://dx.doi.org/10.1016/0041-0101(92)90505-Y] [PMID: 1595082]
[32]
Queiroz, G.P.; Pessoa, L.A.; Portaro, F.C. Furtado, Mde.F.; Tambourgi, D.V. Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus. Toxicon, 2008, 52(8), 842-851.
[http://dx.doi.org/10.1016/j.toxicon.2008.10.002] [PMID: 18983867]
[33]
Bustillo, S.; Leiva, L.C.; Merino, L.; Acosta, O.; Bal de Kier Joffé, E.; Gorodner, J.O. Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine. Rev. Latinoam. Microbiol., 2008, 50, 78-81.
[34]
Bustillo, S.; Lucero, H.; Leiva, L.C.; Acosta, O.; Bal de Kier Joffé, E.; Gorodner, J.O. Cytotoxicity and morphological analysis of cell death induced by Bothrops venoms from north east of Argentina. J. Venom. Anim. Toxins Incl. Trop. Dis., 2009, 15(1), 28-42.
[http://dx.doi.org/10.1590/S1678-91992009000100004]
[35]
Georgieva, D.; Arni, R.K.; Betzel, C. Proteome analysis of snake venom toxins: pharmacological insights. Expert Rev. Proteomics, 2008, 5(6), 787-797.
[http://dx.doi.org/10.1586/14789450.5.6.787] [PMID: 19086859]
[36]
Gutiérrez, J.M.; Lomonte, B.; León, G.; Alape-Girón, A.; Flores-Díaz, M.; Sanz, L.; Angulo, Y.; Calvete, J.J. Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming. J. Proteomics, 2009, 72(2), 165-182.
[http://dx.doi.org/10.1016/j.jprot.2009.01.008] [PMID: 19344652]
[37]
Öhler, M.; Georgieva, D.; Seifert, J.; von Bergen, M.; Arni, R.K.; Genov, N.; Betzel, C. The venomics of Bothrops alternatus is a pool of acidic proteins with predominant hemorrhagic and coagulopathic activities. J. Proteome Res., 2010, 9(5), 2422-2437.
[http://dx.doi.org/10.1021/pr901128x] [PMID: 20329766]
[38]
Cardoso, K.C.; Da Silva, M.J.; Costa, G.G.; Torres, T.T.; Del Bem, L.E.V.; Vidal, R.O.; Menossi, M.; Hyslop, S. A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu). BMC Genomics, 2010, 11(1), 605.
[http://dx.doi.org/10.1186/1471-2164-11-605] [PMID: 20977763]
[39]
Chippaux, J.P.; Williams, V.; White, J. Snake venom variability: methods of study, results and interpretation. Toxicon, 1991, 29(11), 1279-1303.
[http://dx.doi.org/10.1016/0041-0101(91)90116-9] [PMID: 1814005]
[40]
Cominetti, M.R.; Ribeiro, J.U.; Fox, J.W.; Selistre-de-Araujo, H.S. BaG, a new dimeric metalloproteinase/disintegrin from the Bothrops alternatus snake venom that interacts with alpha5beta1 integrin. Arch. Biochem. Biophys., 2003, 416(2), 171-179.
[http://dx.doi.org/10.1016/S0003-9861(03)00298-4] [PMID: 12893294]
[41]
Costa, J.O.; Petri, C.B.; Hamaguchi, A.; Homsi-Brandeburgo, M.I.; Oliveira, C.Z.; Soares, A.M.; Oliveira, F. Purification and functional characterization of two fibrinogenolytic enzymes from Bothrops alternatus venom. J. Venom. Anim. Toxins Incl. Trop. Dis., 2007, 13, 640-654.
[http://dx.doi.org/10.1590/S1678-91992007000300007]
[42]
Smolka, M.B.; Marangoni, S.; Oliveira, B.; Novello, J.C. Purification and partial characterization of a thrombin-like enzyme, balterobin, from the venom of Bothrops alternatus. Toxicon, 1998, 36(7), 1059-1063.
[http://dx.doi.org/10.1016/S0041-0101(98)80008-1] [PMID: 9690798]
[43]
Costa, J. O.; Fonseca, K.C.; Mamede, C.C.; Beletti, M.E.; Santos-Filho, N.A.; Soares, A.M.; Arantes, E.C.; Hirayama, S.N.; Selistre-de-Araújo, H.S.; Fonseca, F.; Henrique-Silva, F.; Penha-Silva, N.; de Oliveira, F. Bhalternin: Functional and structural characterization of a new thrombin-like enzyme from Bothrops alternatus snake venom. Toxicon, 2010, 55(7), 1365-1377.
[http://dx.doi.org/10.1016/j.toxicon.2010.02.014] [PMID: 20184912]
[44]
Fernandes de Oliveira, L.M.; Ullah, A.; Masood, R.; Zelanis, A.; Spencer, P.J.; Serrano, S.M.T.; Arni, R.K. Rapid purification of serine proteinases from Bothrops alternatus and Bothrops moojeni venoms. Toxicon, 2013, 76, 282-290.
[http://dx.doi.org/10.1016/j.toxicon.2013.10.016] [PMID: 24140922]
[45]
Castro, H.C.; Dutra, D.L.; Oliveira-Carvalho, A.L.; Zingali, R.B. Bothroalternin, a thrombin inhibitor from the venom of Bothrops alternatus. Toxicon, 1998, 36(12), 1903-1912.
[http://dx.doi.org/10.1016/S0041-0101(98)00111-1] [PMID: 9839674]
[46]
Ponce-Soto, L.A.; Lomonte, B.; Gutiérrez, J.M.; Rodrigues-Simioni, L.; Novello, J.C.; Marangoni, S. Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus. Biochim. Biophys. Acta, 2007, 1770(4), 585-593.
[http://dx.doi.org/10.1016/j.bbagen.2006.11.015] [PMID: 17270350]
[47]
Setúbal, S.S.; Pontes, A.S.; Furtado, J.L.; Xavier, C.V.; Silva, F.L.; Kayano, A.M.; Izidoro, L.F.M.; Soares, A.M.; Calderon, L.A.; Stábeli, R.G.; Zuliani, J.P. Action of two phospholipases A2 purified from Bothrops alternatus snake venom on macrophages. Biochemistry, 2013, 78(2), 194-203.
[http://dx.doi.org/10.1134/S0006297913020089] [PMID: 23581990]
[48]
Valério, A.A.; Corradini, A.C.; Panunto, P.C.; Mello, S.M.; Hyslop, S. Purification and characterization of a phosphodiesterase from Bothrops alternatus snake venom. J. Protein Chem., 2002, 21(8), 495-503.
[http://dx.doi.org/10.1023/A:1022414503995] [PMID: 12638651]
[49]
Stábeli, R.G.; Marcussi, S.; Carlos, G.B.; Pietro, R.C.; Selistre-de-Araújo, H.S.; Giglio, J.R.; Oliveira, E.B.; Soares, A.M. Platelet aggregation and antibacterial effects of an l-amino acid oxidase purified from Bothrops alternatus snake venom. Bioorg. Med. Chem., 2004, 12(11), 2881-2886.
[http://dx.doi.org/10.1016/j.bmc.2004.03.049] [PMID: 15142548]
[50]
Serrano, S.M.T.; Reichl, A.P.; Mentele, R.; Auerswald, E.A.; Santoro, M.L.; Sampaio, C.A.M.; Camargo, A.C.M.; Assakura, M.T. A novel phospholipase A2, BJ-PLA2, from the venom of the snake Bothrops jararaca: purification, primary structure analysis, and its characterization as a platelet-aggregation-inhibiting factor. Arch. Biochem. Biophys., 1999, 367(1), 26-32.
[http://dx.doi.org/10.1006/abbi.1999.1230] [PMID: 10375395]
[51]
Andrião-Escarso, S.H.; Soares, A.M.; Fontes, M.R.; Fuly, A.L.; Corrêa, F.M.; Rosa, J.C.; Greene, L.J.; Giglio, J.R. Structural and functional characterization of an acidic platelet aggregation inhibitor and hypotensive phospholipase A(2) from Bothrops jararacussu snake venom. Biochem. Pharmacol., 2002, 64(4), 723-732.
[http://dx.doi.org/10.1016/S0006-2952(02)01210-8] [PMID: 12167491]
[52]
Murakami, M.T.; Michelan-Duarte, S.; Cintra, A.C.; Arni, R.K. Crystallization and high-resolution X-ray diffraction data collection of an Asp49 PLA2 from Bothrops jararacussu venom both in the presence and absence of Ca2+ ions. Biochim. Biophys. Acta, 2004, 1703(1), 79-81.
[http://dx.doi.org/10.1016/j.bbapap.2004.08.008] [PMID: 15588705]
[53]
de Albuquerque Modesto, J.C.; Spencer, P.J.; Fritzen, M.; Valença, R.C.; Oliva, M.L.; da Silva, M.B.; Chudzinski-Tavassi, A.M.; Guarnieri, M.C. BE-I-PLA2, a novel acidic phospholipase A2 from Bothrops erythromelas venom: isolation, cloning and characterization as potent anti-platelet and inductor of prostaglandin I2 release by endothelial cells. Biochem. Pharmacol., 2006, 72(3), 377-384.
[http://dx.doi.org/10.1016/j.bcp.2006.04.032] [PMID: 16750518]
[54]
Garcia Denegri, M.E.; Bustillo, S.; Romero-Vargas, F.; Leiva, L.; Acosta, O. Pharmacological activities of Ba SpII RP4 PLA2 from Bothrops alternatus snake venom. Rev. Vet., 2012, 23(1), 25-31.
[55]
Bustillo, S.; Gay, C.C.; García Denegri, M.E.; Ponce-Soto, L.A.; Bal de Kier Joffé, E.; Acosta, O.; Leiva, L.C. Synergism between baltergin metalloproteinase and Ba SPII RP4 PLA2 from Bothrops alternatus venom on skeletal muscle (C2C12) cells. Toxicon, 2012, 59(2), 338-343.
[http://dx.doi.org/10.1016/j.toxicon.2011.11.007] [PMID: 22133569]
[56]
Garcia Denegri, M.E.; Maruñak, S.; Todaro, J.S.; Ponce-Soto, L.A.; Acosta, O.; Leiva, L. Neutralisation of the pharmacological activities of Bothrops alternatus venom by anti-PLA2 IgGs. Toxicon, 2014, 86, 89-95.
[http://dx.doi.org/10.1016/j.toxicon.2014.05.016] [PMID: 24878372]
[57]
Calvete, J.J.; Moreno-Murciano, M.P.; Theakston, R.D.G.; Kisiel, D.G.; Marcinkiewicz, C. Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering. Biochem. J., 2003, 372(Pt 3), 725-734.
[http://dx.doi.org/10.1042/bj20021739] [PMID: 12667142]
[58]
Kini, R.M.; Evans, H.J. Structural domains in venom proteins: evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursor. Toxicon, 1992, 30(3), 265-293.
[http://dx.doi.org/10.1016/0041-0101(92)90869-7] [PMID: 1529462]
[59]
Moura-da-Silva, A.M.; Della-Casa, M.S.; David, A.S.; Assakura, M.T.; Butera, D.; Lebrun, I.; Shannon, J.D.; Serrano, S.M.; Fox, J.W. Evidence for heterogeneous forms of the snake venom metalloproteinase jararhagin: a factor contributing to snake venom variability. Arch. Biochem. Biophys., 2003, 409(2), 395-401.
[http://dx.doi.org/10.1016/S0003-9861(02)00598-2] [PMID: 12504907]
[60]
Laustsen, A.H. Toxin synergism in snake venoms. Toxin Rev., 2016, 35(3-4), 165-170.
[http://dx.doi.org/10.1080/15569543.2016.1220397]
[61]
Calvete, J.J.; Lomonte, B. A bright future for integrative venomics. Toxicon, 2015, 107, 159-162.
[http://dx.doi.org/10.1016/j.toxicon.2015.10.024]
[62]
Xiong, S.; Huang, C. Synergistic strategies of predominant toxins in snake venoms. Toxicol. Lett., 2018, 287, 142-154.
[http://dx.doi.org/10.1016/j.toxlet.2018.02.004] [PMID: 29428543]
[63]
Bustillo, S.; García-Denegri, M.E.; Gay, C.; Van de Velde, A.C.; Acosta, O.; Angulo, Y.; Lomonte, B.; Gutiérrez, J.M.; Leiva, L. Phospholipase A(2) enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis. Chem. Biol. Interact., 2015, 240, 30-36.
[http://dx.doi.org/10.1016/j.cbi.2015.08.002] [PMID: 26279213]
[64]
Arce, V.; Brenes, F.; Gutiérrez, J.M. Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: a histochemical and immunocytochemical study. Int. J. Exp. Pathol., 1991, 72(2), 211-226.
[PMID: 1707650]
[65]
Salvini, T.F.; Belluzzo, S.S.; Selistre de Araújo, H.S.; Souza, D.H. Regeneration and change of muscle fiber types after injury induced by a hemorrhagic fraction isolated from Agkistrodon contortrix laticinctus venom. Toxicon, 2001, 39(5), 641-649.
[http://dx.doi.org/10.1016/S0041-0101(00)00188-4] [PMID: 11072042]
[66]
Mamede, C.C.N.; de Queiroz, M.R.; Fonseca, K.C.; de Morais, N.C.; Filho, S.A.; Beletti, M.E.; Stanziola, L.; de Oliveira, F. Histological and ultrastructural analyses of muscle damage induced by a myotoxin isolated from Bothrops alternatus snake venom. Protein Pept. Lett., 2013, 20(2), 192-199.
[http://dx.doi.org/10.2174/092986613804725352] [PMID: 22894157]
[67]
Hernández, R.; Cabalceta, C.; Saravia-Otten, P.; Chaves, A.; Gutiérrez, J.M.; Rucavado, A. Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves. PLoS One, 2011, 6(5)e19834
[http://dx.doi.org/10.1371/journal.pone.0019834] [PMID: 21629691]
[68]
Allbrook, D. Skeletal muscle regeneration. Muscle Nerve, 1981, 4(3), 234-245.
[http://dx.doi.org/10.1002/mus.880040311] [PMID: 7017402]
[69]
Plaghki, L. Regeneration et myogenese du muscle strie. J. Physiol., 1985, 80, 51-110.
[70]
de Oliveira, V.C.; Lanari, L.C.; Hajos, S.E.; de Roodt, A.R. Toxicity of Bothrops neuwiedi complex (“yarará chica”) venom from different regions of Argentina (Serpentes, Viperidae). Toxicon, 2011, 57(5), 680-685.
[http://dx.doi.org/10.1016/j.toxicon.2011.01.012] [PMID: 21300078]
[71]
Silva, V.X. The Bothrops neuwiedi complex. The Venomous Reptiles of the Western Hemisphere; Campbell, J.A; Lamar, W.W., Ed.; Cornell University Press: New York, 2004, Vol. 2, pp. 410-422.
[72]
Silva, V.X.; Rodrigues, M.F. Taxonomic revision of the Bothrops neuwiedi complex (Serpentes, Viperidae) with description of a new species. Phyllomedusa, 2008, 7, 45-90.
[http://dx.doi.org/10.11606/issn.2316-9079.v7i1p45-90]
[73]
Maruñak, S.; Nuñez, S.; Fernández, C. Leiva, L.; Acosta de Pérez, O. Acción del veneno de Bothrops diporus (yarará chica) del nordeste argentino sobre la hemostasia en diferentes mamíferos. Rev. Vet., 2010, 21(1), 43-47.
[74]
Gay, C.; Sanz, L.; Calvete, J.J.; Pla, D. Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina. Toxins (Basel), 2015, 8(1), 9.
[http://dx.doi.org/10.3390/toxins8010009] [PMID: 26712790]
[75]
de Roodt, A.R.; Lanari, L.C.; de Oliveira, V.C.; Laskowicz, R.D.; Stock, R.P. Neutralization of Bothrops alternatus regional venom pools and individual venoms by antivenom: A systematic comparison. Toxicon, 2011, 57(7-8), 1073-1080.
[http://dx.doi.org/10.1016/j.toxicon.2011.04.013] [PMID: 21549143]
[76]
de Roodt, A.R.; Dolab, J.A.; Fernández, T.; Segre, L.; Hajos, S.E. Cross-reactivity and heterologous neutralization of crotaline antivenoms used in Argentina. Toxicon, 1998, 36(7), 1025-1038.
[http://dx.doi.org/10.1016/S0041-0101(97)00111-6] [PMID: 9690795]
[77]
Ponce Soto, L.A.; Romero Vargas, F.F.; Torres Huaco, F.D.; Gay, C.C. Rodríguez. JP.; Maruñak, S.L.; Teibler, G.P.; Vera Gonzáles, C.A.; Leiva, L.C.; Marangoni, S.; Acosta, O.C. In:. Myotoxic effect and histological damage of the venoms from two, Bothrops diporus species, Proceedings of the 11th Congress of the Brazilian Society of Toxinology, Natural Toxins, Minas Gerais, Brazil, 2010.
[78]
Leiva, L.C.; Garcia Denegri, M.E.; Bustillo, S.; Acosta, O.C.; Maruñak, S.L.; Teibler, G.P.; Ponce Soto, L.A.; Vera Gonzáles, C.A.; Torres Huaco, F.D.; Romero Vargas, F.F.; Marangoni, S. In: Comparison of the hemolytic and antibacterial activities in venoms from two Bothrops species of south American (Bothrops diporus from Brazil and Bothrops diporus from Argentina), Proceedings of the 11th Congress of the Brazilian Society of Toxinology. Natural Toxins: Current Knowledge and New Challenges, Minas Gerais, Brazil, 2010.
[79]
Escalante, T.; Rucavado, A.; Fox, J.W.; Gutiérrez, J.M. Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases. J. Proteomics, 2011, 74(9), 1781-1794.
[http://dx.doi.org/10.1016/j.jprot.2011.03.026] [PMID: 21447411]
[80]
Gutiérrez, J.M.; Ownby, C.L. Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity. Toxicon, 2003, 42(8), 915-931.
[http://dx.doi.org/10.1016/j.toxicon.2003.11.005] [PMID: 15019491]
[81]
Daniele, J.J.; Bianco, I.D.; Delgado, C.; Carrillo, D.B.; Fidelio, G.D. A new phospholipase A2 isoform isolated from Bothrops neuwiedii (Yarará chica) venom with novel kinetic and chromatographic properties. Toxicon, 1997, 35(8), 1205-1215.
[http://dx.doi.org/10.1016/S0041-0101(97)00023-8] [PMID: 9278970]
[82]
Luft, F.C. The Bothrops legacy: vasoactive peptides from Brazil. J. Renin Angiotensin Aldosterone Syst., 2008, 9(1), 57-64.
[http://dx.doi.org/10.3317/jraas.2008.009] [PMID: 18404610]
[83]
Stábeli, R.G.; Marcussi, S.; Carlos, G.B.; Pietro, R.C.; Selistre-de-Araújo, H.S.; Giglio, J.R.; Oliveira, E.B.; Soares, A.M. Platelet aggregation and antibacterial effects of an l-amino acid oxidase purified from Bothrops alternatus snake venom. Bioorg. Med. Chem., 2004, 12(11), 2881-2886.
[http://dx.doi.org/10.1016/j.bmc.2004.03.049] [PMID: 15142548]
[84]
Markland, F.S. Snake venoms and the hemostatic system. Toxicon, 1998, 36(12), 1749-1800.
[http://dx.doi.org/10.1016/S0041-0101(98)00126-3] [PMID: 9839663]
[85]
Daniele, J.J.; Bianco, I.D.; Fidelio, G.D. Kinetic and pharmacologic characterization of phospholipases A2 from Bothrops neuwiedii venom. Arch. Biochem. Biophys., 1995, 318(1), 65-70.
[http://dx.doi.org/10.1006/abbi.1995.1205] [PMID: 7726575]
[86]
Geoghegan, P.; Angulo, Y.; Cangelosi, A.; Díaz, M.; Lomonte, B. Characterization of a basic phospholipase A2-homologeu myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarará chica) from Argentina. Toxicon, 1999, 37(12), 1735-1746.
[http://dx.doi.org/10.1016/S0041-0101(99)00115-4] [PMID: 10519651]
[87]
Teixera, L.F.; de Carvalho, L.H.; de Castro, O.B.; Bastos, J.S.F.; Néry, N.M.; Oliveira, G.A.; Kayano, A.M.; Soares, A.M.; Zuliani, J.P. Local and systemic effects of BdipTX-I, a Lys-49 phospholipase A2 isolated from Bothrops diporus snake venom. Toxicon, 2018, 141, 55-64.
[http://dx.doi.org/10.1016/j.toxicon.2017.11.007] [PMID: 29170054]
[88]
Yunes Quartino, P.J.; Barra, J.L.; Fidelio, G.D. Cloning and functional expression of secreted phospholipases A(2) from Bothrops diporus (Yarará Chica). Biochem. Biophys. Res. Commun., 2012, 427(2), 321-325.
[http://dx.doi.org/10.1016/j.bbrc.2012.09.051] [PMID: 22995294]
[89]
Campbell, J.A.; Lamar, W.W. The Venomous Reptiles of the Western Hemisphere; Cornell University Press: Ithaca, New York, 2004, Vol. I, .
[90]
McDiarmid, R.W.; Campbell, J.A.; Touré, T. Snake species of the world: A taxonomic and geographic reference. v. 1. Herpetologists' League; Washington, DC, 1999, pp.511.
[91]
Warrell, D. Snakebites in Central and South America: Epidemiology, clinical features, and clinical management. The venomous reptiles of the western hemisphere, 2004. 1, 709-761.
[92]
Acosta de Perez, O.; Koscinczuk, P.; Teibler, P.; Ruiz, R.; Sanchez Negrette, M.; Maruñak, S.; Mussart de Coppo, N. Intoxicación por veneno de Crotalus durissus terrificus (cascabel) en ratas. Acta Toxicol. Argent., 1997, 5(2), 71-74.
[93]
Hendon, R.A.; Fraenkel-Conrat, H. The role of complex formation in the neurotoxicity of crotoxin components A and B. Toxicon, 1976, 14(4), 283-289.
[http://dx.doi.org/10.1016/0041-0101(76)90024-6] [PMID: 960111]
[94]
Cupo, P.; Azevedo-Marques, M.M.; Hering, S.E. Clinical and laboratory features of South American rattlesnake (Crotalus durissus terrificus) envenomation in children. Trans. R. Soc. Trop. Med. Hyg., 1988, 82(6), 924-929.
[http://dx.doi.org/10.1016/0035-9203(88)90044-2] [PMID: 3257000]
[95]
Rosenfeld, G. Symptomatology, pathology and treatment of snake bites in South America. Venomous animals and their venoms, 1971. 2, 345-384.
[96]
de Sousa-e-Silva, M.C.; Tomy, S.C.; Tavares, F.L.; Navajas, L.; Larsson, M.H.; Lucas, S.R.; Kogika, M.M.; Sano-Martins, I.S. Hematological, hemostatic and clinical chemistry disturbances induced by Crotalus durissus terrificus snake venom in dogs. Hum. Exp. Toxicol., 2003, 22(9), 491-500.
[http://dx.doi.org/10.1191/0960327103ht392oa] [PMID: 14580009]
[97]
Ownby, C.L. Pathology of rattlesnake evenomation.Rattlesnake Venoms, Their Actions and Treatment; Tu, A.T., Ed.; Marcel Dekker: New York, 1982, pp. 163-209.
[98]
Amaral, C.F.; da Silva, O.A.; López, M.; Pedroso, E.R. Afibrinogenemia following snake bite (Crotalus durissus terrificus). Am. J. Trop. Med. Hyg., 1980, 29(6), 1453-1455.
[http://dx.doi.org/10.4269/ajtmh.1980.29.1453] [PMID: 7446831]
[99]
Azevedo-Marques, M.M.; Cupo, P.; Coimbra, T.M.; Hering, S.E.; Rossi, M.A.; Laure, C.J. Myonecrosis, myoglobinuria and acute renal failure induced by South American rattlesnake (Crotalus durissus terrificus) envenomation in Brazil. Toxicon, 1985, 23(4), 631-636.
[http://dx.doi.org/10.1016/0041-0101(85)90367-8] [PMID: 4060176]
[100]
Rodríguez, J.P.; De Marzi, M.C.; Maruñak, S.; Teibler, P.; Acosta, O.; Malchiodi, E.L.; Leiva, L.C. IgG antibodies against phospholipase A2 from Crotalus durissus terrificus: cross-reaction with venoms from Bothrops species from Argentina. J. Venom. Anim. Toxins Incl. Trop. Dis., 2009, 15, 460-478.
[http://dx.doi.org/10.1590/S1678-91992009000300008]
[101]
Fusco, L.S.; Rodríguez, J.P.; Teibler, P.; Maruñak, S.; Acosta, O.; Leiva, L. New immunization protocol to produce crotalic antivenom combining Crotalus durissus terrificus venom and its PLA2. Biologicals, 2015, 43(1), 62-70.
[http://dx.doi.org/10.1016/j.biologicals.2014.09.001] [PMID: 25453603]
[102]
Boldrini-França, J.; Corrêa-Netto, C.; Silva, M.M.S.; Rodrigues, R.S.; De La Torre, P.; Pérez, A.; Soares, A.M.; Zingali, R.B.; Nogueira, R.A.; Rodrigues, V.M.; Sanz, L.; Calvete, J.J. Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management. J. Proteomics, 2010, 73(9), 1758-1776.
[http://dx.doi.org/10.1016/j.jprot.2010.06.001] [PMID: 20542151]
[103]
Congreses - Argentine Toxicological Association.. https://www. toxicologia.org.ar/congresos/ (Accessed 2002).
[104]
Rangel-Santos, A.; Dos-Santos, E.C.; Lopes-Ferreira, M.; Lima, C.; Cardoso, D.F.; Mota, I. A comparative study of biological activities of crotoxin and CB fraction of venoms from Crotalus durissus terrificus, Crotalus durissus cascavella and Crotalus durissus collilineatus. Toxicon, 2004, 43(7), 801-810.
[http://dx.doi.org/10.1016/j.toxicon.2004.03.011] [PMID: 15284014]
[105]
Santoro, M.L.; Sousa-e-Silva, M.C.C.; Gonçalves, L.R.C.; Almeida-Santos, S.M.; Cardoso, D.F.; Laporta-Ferreira, I.L.M.; Saiki, M.; Peres, C.A.; Sano-Martins, I.S. Comparison of the biological activities in venoms from three subspecies of the South American rattlesnake (Crotalus durissus terrificus, C. durissus cascavella and C. durissus collilineatus). Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol., 1999, 122(1), 61-73.
[http://dx.doi.org/10.1016/S0742-8413(98)10079-8] [PMID: 10190029]
[106]
Dos Santos, M.C.; Ferreira, L.C.; Da Silva, W.D.; Furtado, M.F. Characterization of the biological activities of the ‘yellow’ and ‘white’ venoms from Crotalus durissus ruruima compared with the Crotalus durissus terrificus venom. Neutralizing activity of Crotalus durissus ruruima antivenins. Toxicon, 1993, 31(11), 1459-1469.
[http://dx.doi.org/10.1016/0041-0101(93)90211-Z] [PMID: 8310446]
[107]
Rodríguez, J.; Gay, C.; Fusco, L.; Gauna, M.; Acosta, O.; Leiva, L. Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom. J. Venom. Anim. Toxins Incl. Trop. Dis., 2012, 18(1), 116-123.
[http://dx.doi.org/10.1590/S1678-91992012000100015]
[108]
Fusco, L.S.; Rodríguez, J.P.; Torres-Huaco, F.; Huancahuire-Vega, S.; Teibler, P.; Acosta, O.; Marangoni, S.; Ponce-Soto, L.A.; Leiva, L.C. P9a(Cdt-PLA2) from Crotalus durissus terrificus as good immunogen to be employed in the production of crotalic anti-PLA2 IgG. Toxicol. Lett., 2015, 238(1), 7-16.
[http://dx.doi.org/10.1016/j.toxlet.2015.06.528] [PMID: 26129711]
[109]
Ponce-Soto, L.A.; Toyama, M.H.; Hyslop, S.; Novello, J.C.; Marangoni, S. Isolation and preliminary enzymatic characterization of a novel PLA2 from Crotalus durissus collilineatus venom. J. Protein Chem., 2002, 21(3), 131-136.
[http://dx.doi.org/10.1023/A:1015332314389] [PMID: 12018613]
[110]
Salvini, T.F.; Amaral, A.C.; Miyabara, E.H.; Turri, J.A.; Danella, P.M.; Selistre de Araújo, H.S. Systemic skeletal muscle necrosis induced by crotoxin. Toxicon, 2001, 39(8), 1141-1149.
[http://dx.doi.org/10.1016/S0041-0101(00)00245-2] [PMID: 11306124]
[111]
Mebs, D.; Ownby, C.L. Myotoxic components of snake venoms: their biochemical and biological activities. Pharmacol. Ther., 1990, 48(2), 223-236.
[http://dx.doi.org/10.1016/0163-7258(90)90081-C] [PMID: 2293240]
[112]
Jorge, M.T.; Ribeiro, L.A. Epidemiologia e quadro clínico do acidente por cascavel sul-americana (Crotalus durissus). Rev. Inst. Med. Trop. São Paulo, 1992, 34(4), 347-354.
[http://dx.doi.org/10.1590/S0036-46651992000400013] [PMID: 1342093]
[113]
Silveira, P.V. Nishioka, Sde.A. South American rattlesnake bite in a Brazilian teaching hospital. Clinical and epidemiological study of 87 cases, with analysis of factors predictive of renal failure. Trans. R. Soc. Trop. Med. Hyg., 1992, 86(5), 562-564.
[http://dx.doi.org/10.1016/0035-9203(92)90114-R] [PMID: 1475835]
[114]
Calvete, J.J.; Sanz, L.; Cid, P.; de la Torre, P.; Flores-Díaz, M.; Dos Santos, M.C.; Borges, A.; Bremo, A.; Angulo, Y.; Lomonte, B.; Alape-Girón, A.; Gutiérrez, J.M. Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America. J. Proteome Res., 2010, 9(1), 528-544.
[http://dx.doi.org/10.1021/pr9008749] [PMID: 19863078]
[115]
Georgieva, D.; Öhler, M.; Seifert, J.; von Bergen, M.; Arni, R.K.; Genov, N.; Betzel, C. Snake venomic of Crotalus durissus terrificus--correlation with pharmacological activities. J. Proteome Res., 2010, 9(5), 2302-2316.
[http://dx.doi.org/10.1021/pr901042p] [PMID: 20205475]
[116]
Canziani, G.; Seki, C.; Vidal, J.C. Accessibility of the active site of crotoxin B in the crotoxin complex. Toxicon, 1982, 20(5), 809-822.
[http://dx.doi.org/10.1016/0041-0101(82)90068-X] [PMID: 7179290]
[117]
Faure, G.; Bon, C. Crotoxin, a phospholipase A2 neurotoxin from the South American rattlesnake Crotalus durissus terrificus: purification of several isoforms and comparison of their molecular structure and of their biological activities. Biochemistry, 1988, 27(2), 730-738.
[http://dx.doi.org/10.1021/bi00402a036] [PMID: 3349062]
[118]
Camillo, M.A.; Arruda Paes, P.C.; Troncone, L.R.; Rogero, J.R. Gyroxin fails to modify in vitro release of labelled dopamine and acetylcholine from rat and mouse striatal tissue. Toxicon, 2001, 39(6), 843-853.
[http://dx.doi.org/10.1016/S0041-0101(00)00222-1] [PMID: 11137545]
[119]
Raw, I.; Rocha, M.C.; Esteves, M.I.; Kamiguti, A.S. Isolation and characterization of a thrombin-like enzyme from the venom of Crotalus durissus terrificus. Braz. J. Med. Biol. Res., 1986, 19(3), 333-338.
[PMID: 3594000]
[120]
Fox, J.W. A brief review of the scientific history of several lesser-known snake venom proteins: l-amino acid oxidases, hyaluronidases and phosphodiesterases. Toxicon, 2013, 62, 75-82.
[http://dx.doi.org/10.1016/j.toxicon.2012.09.009] [PMID: 23010165]
[121]
Fusco, L.S. Frank Torres-Huaco; Hyslop, S.; Leiva, L.C. Isolation of phosphodiesterase from the venom of Crotalus durissus terrificus. In: XVIII Annual Meeting of the Argentine Biology Society. Buenos Aires, Argentina. Biocell, 2016, 40(Suppl. 2), A74.https://www.mendoza.conicet.gov.ar/portal//biocell/XVIII_Annual_Meeting.pdf
[122]
Horst, J.; Hendon, R.A.; Fraenkel-Conrat, H. The active components of crotoxin. Biochem. Biophys. Res. Commun., 1972, 46(3), 1042-1047.
[http://dx.doi.org/10.1016/S0006-291X(72)80077-9] [PMID: 5062419]
[123]
Ruiz de Torrent, R.M.; Bongiovanni, B.; Leiva, L.C.; Evangelista de Duffard, A.M.; Rodríguez, J.P.; Acosta de Pérez, O.C.; Duffard, R. Neurotoxicological effects of a thrombin-like enzyme isolated from Crotalus durissus terrificus venom (preliminary study). Toxicon, 2007, 50(1), 144-152.
[http://dx.doi.org/10.1016/j.toxicon.2007.03.009] [PMID: 17467764]
[124]
Mitra, J.; Bhattacharyya, D. Phosphodiesterase from Daboia russelli russelli venom: Purification, partial characterization and inhibition of platelet aggregation. Toxicon, 2014, 88, 1-10.
[http://dx.doi.org/10.1016/j.toxicon.2014.06.004] [PMID: 24932740]
[125]
Gonçalves, J.M.; Vieira, L.G. Estudos sobre venenos de serpentes brasileiras. I. Análise eletroforética. An. Acad. Bras. Cienc., 1950, 22, 141-150.
[126]
Gonçalves, J. Purification and properties of crotamine. Venoms, 1956, 44, 261-273.
[127]
Beltran, J.R.; Mascarenhas, Y.P.; Craievich, A.F.; Laure, C.J. SAXS study of the snake toxin α-crotamine. Eur. Biophys. J., 1990, 17(6), 325-329.
[http://dx.doi.org/10.1007/BF00258381] [PMID: 2307140]
[128]
Oguiur, N.; Camargo, M.E.; da Silva, A.R.P.; Horton, D.S.P.Q. Quantification of crotamine, a small basic myotoxin, in South American rattlesnake (Crotalus durissus terrificus) venom by enzyme-linked immunosorbent assay with parallel-lines analysis. Toxicon, 2000, 38(3), 443-448.
[http://dx.doi.org/10.1016/S0041-0101(99)00157-9] [PMID: 10669031]
[129]
Lourenço, A., Jr; Zorzella Creste, C.F.; de Barros, L.C.; Delazari dos Santos, L.; Pimenta, D.C.; Barraviera, B.; Ferreira, R.S., Jr Individual venom profiling of Crotalus durissus terrificus specimens from a geographically limited region: crotamine assessment and captivity evaluation on the biological activities. Toxicon, 2013, 69, 75-81.
[http://dx.doi.org/10.1016/j.toxicon.2013.01.006] [PMID: 23380403]
[130]
Cameron, D.L.; Tu, A.T. Chemical and functional homology of myotoxin a from prairie rattlesnake venom and crotamine from South American rattlesnake venom. Biochim. Biophys. Acta, 1978, 532(1), 147-154.
[http://dx.doi.org/10.1016/0005-2795(78)90457-9] [PMID: 620050]
[131]
Brazil, O.V.; Fontana, M.D. Toxins as tools in the study of sodium channel distribution in the muscle fibre membrane. Toxicon, 1993, 31(9), 1085-1098.
[http://dx.doi.org/10.1016/0041-0101(93)90124-2] [PMID: 8266342]
[132]
Echeverría, M.S.; Gauna, M.P.; Bustillo, S.; Leiva, L.C.; Fusco, L.S. Isolation of crotamine from venom of Argenitinian rattlesnake. In: XVIII Annual Meeting of the Argentine Biology Society. Buenos Aires, Argentina. Biocell, 2016, 40(Suppl. 2), A-71.
[133]
Mancin, A.C.; Soares, A.M.; Andrião-Escarso, S.H.; Faça, V.M.; Greene, L.J.; Zuccolotto, S.; Pelá, I.R.; Giglio, J.R. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon, 1998, 36(12), 1927-1937.
[http://dx.doi.org/10.1016/S0041-0101(98)00117-2] [PMID: 9839677]
[134]
Lomonte, B.; Furtado, M.F.; Rovira, M.E.; Carmona, E.; Rojas, G.; Aymerich, R.; Gutiérrez, J.M. South American snake venom proteins antigenically related to Bothrops asper myotoxins. Braz. J. Med. Biol. Res., 1990, 23(5), 427-435.
[PMID: 1710160]
[135]
King, G.F., Ed.; Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics; Royal Society of Chemistry Publishing: Cambridge, UK, 2015.
[http://dx.doi.org/10.1039/9781849737876]
[136]
Koh, D.C.I.; Armugam, A.; Jeyaseelan, K. Snake venom components and their applications in biomedicine. Cell. Mol. Life Sci., 2006, 63(24), 3030-3041.
[http://dx.doi.org/10.1007/s00018-006-6315-0] [PMID: 17103111]
[137]
Soares, A.M. Use of snake venom for biomedical researches and drug development. Open J. Biochem. Biotechnol., 2012, 1, 1-4.

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