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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

PET Imaging of Adenosine Receptors in Diseases

Author(s): Jindian Li, Xingfang Hong, Guoquan Li, Peter S. Conti, Xianzhong Zhang* and Kai Chen*

Volume 19, Issue 16, 2019

Page: [1445 - 1463] Pages: 19

DOI: 10.2174/1568026619666190708163407

Price: $65


Adenosine receptors (ARs) are a class of purinergic G-protein-coupled receptors (GPCRs). Extracellular adenosine is a pivotal regulation molecule that adjusts physiological function through the interaction with four ARs: A1R, A2AR, A2BR, and A3R. Alterations of ARs function and expression have been studied in neurological diseases (epilepsy, Alzheimer’s disease, and Parkinson’s disease), cardiovascular diseases, cancer, and inflammation and autoimmune diseases. A series of Positron Emission Tomography (PET) probes for imaging ARs have been developed. The PET imaging probes have provided valuable information for diagnosis and therapy of diseases related to alterations of ARs expression. This review presents a concise overview of various ARs-targeted radioligands for PET imaging in diseases. The most recent advances in PET imaging studies by using ARs-targeted probes are briefly summarized.

Keywords: Positron emission tomography (PET), Molecular imaging probe, G-protein-coupled receptors (GPCRs), Adenosine receptors (ARs), Diseases, ATP.

Graphical Abstract
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