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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Systematic Review Article

Suicide in Parkinson’s Disease: A Systematic Review

Author(s): Isabella Berardelli, Daniele Belvisi, Adele Nardella, Giulia Falcone, Dorian A. Lamis, Giovanni Fabbrini, Alfredo Berardelli, Paolo Girardi and Maurizio Pompili*

Volume 18, Issue 6, 2019

Page: [466 - 477] Pages: 12

DOI: 10.2174/1871527318666190703093345

Price: $65


Psychiatric disorders and suicide have been reported in patients suffering from Parkinson’s disease. The aims of the present paper were to determine whether patients with Parkinson’s disease have an increased rate of suicide and to identify the clinical features possibly associated with suicide risk in Parkinson’s disease. We also reviewed the studies on suicide risk in Parkinson’s disease in patients after deep brain stimulation. We performed a Medline, Excerpta Medica, PsycLit, PsycInfo and Index Medicus search to identify all articles published on this topic from 1970 to 2019. The following search terms were used: suicide OR suicide attempt OR suicidal ideation OR suicide risk AND Parkinson’s disease AND Parkinson’s disease and deep brain stimulation. The studies we identified that assessed the suicide rate associated with Parkinson’s disease yielded contrasting results, although an increase in suicidal ideation did emerge. The studies on the effect of deep brain stimulation on suicide risk in Parkinson’s disease also reported mixed findings. Psychiatric symptoms, including depression, appear to be associated with suicide risk in patients with Parkinson’s disease undergoing medical and after surgical treatment. The studies reviewed suggest that suicidal ideation is increased in Parkinson’s disease. Further longitudinal studies designed to assess suicidality in this condition are still needed.

Keywords: Suicide risk, suicidal ideation, Parkinson’s disease, deep brain stimulation, psychiatric disorders, depression.

Graphical Abstract
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