Title:Intercellular Crosstalk Via Extracellular Vesicles in Tumor Milieu as Emerging Therapies for Cancer Progression
Volume: 25
Issue: 17
Author(s): Laura Patras and Manuela Banciu*
Affiliation:
- Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca,Romania
Keywords:
Extracellular vesicles, exosomes, tumor cells, tumor microenvironment, drug delivery systems, bioengineering.
Abstract:
Increasing evidence has suggested that extracellular vesicles (EV) mediated bidirectional transfer of
functional molecules (such as proteins, different types of RNA, and lipids) between cancer cells and tumor stromal
cells (immune cells, endothelial cells, fibroblasts, stem cells) and strongly contributed to the reinforcement of
cancer progression. Thus, intercellular EV-mediated signaling in tumor microenvironment (TME) is essential in
the modulation of all processes that support and promote tumor development like immune suppression, angiogenesis,
invasion and metastasis, and resistance of tumor cells to anticancer treatments.
Besides EV potential to revolutionize our understanding of the cancer cell-stromal cells crosstalk in TME, their
ability to selectively transfer different cargos to recipient cells has created excitement in the field of tumortargeted
delivery of specific molecules for anticancer treatments. Therefore, in tight connection with previous
findings, this review brought insight into the dual role of EV in modulation of TME. Thus, on one side EV create
a favorable phenotype of tumor stromal cells for tumor progression; however, as a future new class of anticancer
drug delivery systems EV could re-educate the TME to overcome main supportive processes for malignancy
progression.
