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Recent Patents on Food, Nutrition & Agriculture


ISSN (Print): 2212-7984
ISSN (Online): 1876-1429

General Review Article

Impact of Curcumin on Traumatic Brain Injury and Involved Molecular Signaling Pathways

Author(s): Tahereh Farkhondeh, Saeed Samarghandian*, Babak Roshanravan and Leila Peivasteh-roudsari

Volume 11, Issue 2, 2020

Page: [137 - 144] Pages: 8

DOI: 10.2174/2212798410666190617161523


Traumatic Brain Injury (TBI) is one of the main causes of mortality and morbidity worldwide with no suitable treatment. The present study was designed to review the present literature about the protective effects of curcumin and the underlying mechanism against TBI. All published English language papers from beginning to 2019 were selected in this study. The findings indicate that curcumin may be effective against TBI outcomes by modulating the molecular signaling pathways involved in oxidative stress, inflammation, apoptosis, and autophagy. However, more experimental studies should be done to identify all mechanisms involved in the pathogenesis of TBI. Patents for Curcumin and chronic inflammation and traumatic brain injury management (WO2017097805A1 and US9101580B2) were published. In conclusion, the present study confirmed the potential therapeutic impact of curcumin for treating TBI.

Keywords: Curcumin, traumatic brain injury, inflammation, oxidative stress, apoptosis, autophagy.

Graphical Abstract
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