Title:Anti-tumor Drug Targets Analysis: Current Insight and Future Prospect
Volume: 20
Issue: 11
Author(s): Sheng Wang, Dexi Zhou, Zhenyu Xu, Jing Song, Xueyi Qian, Xiongwen Lv *Jiajie Luan*
Affiliation:
- The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, School of Pharmacy, Institute for Liver Disease of Anhui Medical University, Hefei, Anhui Province,China
- Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province,China
Keywords:
Anti-tumor drug targets, tyrosine kinase, immune checkpoints, cell cycle, histone deacetylase inhibitor, ubiquitin
proteasome system, therapeutic strategies, microRNAs.
Abstract: The incidence and mortality of malignant tumors are on the rise, which has become the
second leading cause of death in the world. At present, anti-tumor drugs are one of the most common
methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines,
it has been gradually discovered that the essence of cell carcinogenesis is the infinite proliferation
of cells caused by the disorder of cell signal transduction pathways, followed by a major shift
in the concept of anti-tumor drugs research and development. The focus of research and development
is shifting from traditional cytotoxic drugs to a new generation of anti-tumor drugs targeted at abnormal
signaling system targets in tumor cells. In this review, we summarize the targets of anti-tumor
drugs and analyse the molecular mechanisms of their effects, which lay a foundation for subsequent
treatment, research and development.