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Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Case Report

Allopurinol and Loss of Consciousness in a 78-old Year Man Suffering from Gout

Author(s): Mahnaz Arian, Mina AkbariRad*, Ahmad Bagheri Moghaddam, Abdollah Firoozi and Mohammad Jami

Volume 20, Issue 2, 2020

Page: [253 - 256] Pages: 4

DOI: 10.2174/1871526519666190128102039

Price: $65


Allopurinol is an FDA -Approved xanthine oxidase inhibitor, which is effective in the treatment of gout, hyperuricemia and uremic kidney stones in patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine into uric acid, and therefore its inhibition results in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction.

Case Presentation: This report represents a case of drug-induced meningitis of a senile man who ended up in the ICU due to the remarkably reduced state of consciousness.

Keywords: Allopurinol, drug-induced meningitis, bacterial meningitis, consciousnes, gout, hyperuricemia.

Graphical Abstract
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