Title:The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer
Volume: 24
Issue: 32
Author(s): Ashfaq Ur Rehman, Mueed Ur Rahman, Muhammad T. Khan, Shah Saud, Hao Liu, Dong Song, Pinky Sultana, Abdul Wadood and Hai-Feng Chen*
Affiliation:
- State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240,China
Keywords:
Regulation, fatal cancer disease, Protein tyrosine phosphatase, association of Shp2, germline mutation, numerous syndrome.
Abstract: Role of Shp2: The dysregulation of cell signaling cascades associated with the cell differentiation and
growth, due to the deletion, insertion or point mutation in specific amino acids which alters the intrinsic conformation
of the protein, can ultimately lead to a fatal cancer disease. The protein tyrosine phosphatase has been
recognized as a key regulator of extracellular stimuli such as cytokine receptor and receptor tyrosine kinase signaling.
In the last era, the PTPN11 gene (encode a Shp2 protein) and its association with acute myeloid, juvenile
myelomonocytic, and B-cell acute lymphoblastic leukemia, Noonan syndrome, and myelodysplastic have been
recognized as the cause of such deadly disease due to the occurrence of germline mutations in the interface of
PTP and SH2 domain.
Conclusion: The current study was designed to focus on the allosteric regulation (autoinhibition) of the of Shp2
protein. Subsequently, it will cover the last 10-year recap of Shp2 protein, their role in cancer, and regulation in
numerous ways (allosteric regulation).
