Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

Muneeb    U.   Rehman; Adil    Farooq    Wali; Anas       Ahmad; Sheeba       Shakeel; Saiema       Rasool; Rayeesa       Ali; Shazada    Mudasir    Rashid; Hassan       Madkhali; Majid    Ahmad    Ganaie; Rehan       Khan
doi:10.2174/1570159X16666180911124605
Abstract

Nature has bestowed mankind with surplus resources (natural products) on land and water. Natural products have a significant role in the prevention of disease and boosting of health in humans and animals. These natural products have been experimentally documented to possess various biological properties such as antioxidant, anti-inflammatory and anti-apoptotic activities. In vitro and in vivo studies have further established the usefulness of natural products in various preclinical models of neurodegenerative disorders. Natural products include phytoconstituents, like polyphenolic antioxidants, found in herbs, fruits, nuts, vegetables and also in marine and freshwater flora. These phytoconstituents may potentially suppress neurodegeneration and improve memory as well as cognitive functions of the brain. Also, they are known to play a pivotal role in the prevention and cure of different neurodegenerative diseases, such as Alzheimer’s disease, epilepsy, Parkinson’s disease and other neuronal disorders. The large-scale neuro-pharmacological activities of natural products have been documented due to the result of either the inhibition of inflammatory processes, or the up-regulation of various cell survival proteins or a combination of both. Due to the scarcity of human studies on neuroprotective effects of natural products, this review focuses on the various established activities of natural products in in vitro and in vivo preclinical models, and their potential neuro-therapeutic applications using the available knowledge in the literature.
Keywords: Neurological disorders, neuroprotection, plant products, nutraceuticals, natural compounds, chronic neurodegenerative diseases.
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DOI https://dx.doi.org/10.2174/1570159X16666180911124605	Print ISSN 1570-159X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6190
Current Neuropharmacology

Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

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