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Cardiovascular & Hematological Agents in Medicinal Chemistry


ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Review Article

Free Fatty Acids: Circulating Contributors of Metabolic Syndrome

Author(s): Chase Suiter, Santu K. Singha, Rozita Khalili and Zia Shariat-Madar*

Volume 16, Issue 1, 2018

Page: [20 - 34] Pages: 15

DOI: 10.2174/1871525716666180528100002

Price: $65


Metabolic syndrome induces an increased cardiovascular morbidity and mortality. Most importantly, the prevalence of metabolic syndrome in adult population is expanding. Both clinical and preclinical studies indicate that increased Free Fatty Acids (FFAs) are involved in the pathogenesis of insulin resistance and subsequent development of metabolic syndrome. The relevance of FFAs in protecting and restoring tissue function is quite vast. The search to correlate the functional deterioration of the tissues within the cardiovascular system and increased plasma concentrations of FFAs has been reported. The importance of reduction in the consumption of dietary fatty acids along with the identification of dysregulated genes responsible for persistent increased FFAs uptake and mitochondrial -oxidation has been increasingly recognized. This review discusses the current empirical understanding of the different types of fatty acids and their metabolism and functions both in physiological and pathophysiological conditions. We also discuss in detail about the molecular and pathophysiological basis of increased FFAs, which augments Cardiovascular Disease (CVD).

Keywords: Cardiovascular disease, free fatty acids, metabolic syndrome, morbidity, mortality, monosaturated fatty acids.

Graphical Abstract

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