Editorial: The Real Impact of Target Therapy in Cancer Patients: Between Hope and Reality

This thematic issue focuses on hot and emerging areas in cancer drug targets, aiming to compile 10-12 high-quality articles that explore cutting-edge research, including but not limited to the discovery of novel targets, development of targeted therapeutics, clinical translation of promising strategies, and addressing challenges like drug resistance. It seeks ...read more

The dynamic plasticity of immune cells within the tumor microenvironment is a pivotal determinant of cancer progression and treatment response. While transformative, single-cell multi-omics technologies (encompassing transcriptomics, epigenomics, proteomics, and spatial profiling) generate datasets of immense complexity. The true power of this data is unlocked through its systematic integration with ...read more

Neuroblastoma arises from the aberrant development of sympathetic neurons derived from the neural crest. Its pathogenesis remains unclear due to pronounced clinical, biological, and genetic heterogeneity. Despite advances in multimodal treatment, children with high-risk or advanced-stage neuroblastoma still face poor long-term survival. Moreover, intensive chemotherapy in early childhood often causes ...read more

The tumor microenvironment is a complex ecosystem comprising tumor cells, immune cells, stromal cells, signaling molecules, and extracellular matrix components. Tumor metabolism and the immune microenvironment are two critical pillars of cancer biology that are deeply interconnected and play pivotal roles in cancer progression, treatment resistance, and immune surveillance. This ...read more