Title:Role of miR-193a in Cancer: Complexity and Factors Control the Pattern of its Expression
Volume: 18
Issue: 7
Author(s): Afraa Mamoori, Vinod Gopalan and Alfred K-Y Lam*
Affiliation:
- Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland,Australia
Keywords:
miR-193a, cancer, chemotherapy, prognosis, mechanism, methylation.
Abstract: Background: There is emerging data suggesting that the non-coding RNA (microRNA
193a or miR-193a) plays key roles in different types of cancers.
Objective: This review aims to investigate the functional significance of miR-193a in different cancers
according to the information of literature.
Method: All the literature concerning miR-193a in cancer in PubMed are analysed.
Results: Several studies proved the association of miR-193a expression patterns with cancer’s
stages, grades, response to the chemotherapy and even patient survival. Also, miR-193a can be used
to differentiate some types of cancer. In cancer, miR-193a can act as a tumour suppressor gene or as
an oncogene. Till now, several genetic factors (MAX, RXR α, XB130, P63, P73, AEG-1, HIFs,
EGFR, Drosha, DGCR8, Dicer) and epigenetic factors (DNA methylation and long non-coding
RNAs) were predicted to control miR-193a expression. They have fundamental effects on its biological
behaviour in different types of cancers.
Conclusion: miR-193a has significant roles in cancer and can be targeted in the future for cancer
therapy by better understanding of the factors that control its biological behaviour.
