Title:Mesenchymal Stem Cell Therapy in Intracerebral Haemorrhagic Stroke
Volume: 25
Issue: 19
Author(s): Gloria Bedini*, Anna Bersano, Elisa R. Zanier, Francesca Pischiutta and Eugenio A. Parati
Affiliation:
- Laboratory of Cellular Neurobiology, Neurology Unit, UCV; Fondazione IRCCS Istituto Neurologico C. Besta, Milan, 20133,Italy
Keywords:
Angiogenesis, anti-inflammatory properties, intracerebral haemorrhagic stroke, extracellular vesicles,
mesenchymal, stem cells, neuroprotective action, stroke.
Abstract: Background: Spontaneous intracerebral haemorrhage (ICH) is a relatively
common fatal disease, with an overall global incidence estimated at 24.6 per 100,000 person-
years. Given the high degree of morbidity and mortality associated with ICH, therapies
that may have neuroprotective effects are of increasing interest to clinicians. In this
last context, cell therapies offer the promise of improving the disease course which cannot
be addressed adequately by existing treatments.
Objective: The aim of this review is to evaluate the protective effects and molecular
mechanisms of mesenchymal stem cells (MSCs) on haemorrhagic brain following ICH.
We also discuss possible emerging therapeutic approaches worth of further research.
Methods and Results: The available literature on the therapeutic potential of MSCs in
ICH animal models clearly demonstrated that MSCs enhance the functional recovery and
reduce the volume of the infarct size exerting anti-inflammatory and angiogenic properties.
However, the quality of the original articles investigating the efficacy of stem cell
therapies in ICH animal models is still poor and the lack of ICH clinical trial does not
permit to reach any relevant conclusions.
Conclusion: Further studies have to be implemented in order to achieve standardized
methods of MSCs isolation, characterization and administration to improve ICH treatments
with MSCs or MSC-derived products.
