Title:The Emerging Role of Helicobacter Pylori-Induced Metabolic Gastrointestinal Dysmotility and Neurodegeneration
Volume: 17
Issue: 6
Author(s): J. Kountouras*, M. Boziki, S.A. Polyzos, P. Katsinelos, E. Gavalas, C. Zeglinas, D. Tzivras, I. Romiopoulos, N. Giorgakis, K. Anastasiadou, E. Vardaka, C. Kountouras, E. Kazakos, E. Giartza-Taxidou, G. Deretzi, E. Dardiotis, G. Kotronis and M. Doulberis
Affiliation:
- Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki,Greece
Keywords:
Helicobacter pylori, gastrointestinal dysmotility, Alzheimer’s disease, multiple sclerosis, glaucoma,
neurodegeneration.
Abstract: Helicobacter pylori infection (Hp-I) is a prevalent disorder identified in the
majority of the population in many countries around the world and is responsible for
substantial gastrointestinal morbidity. Likewise, neurodegenerative diseases such as
Alzheimer's disease, Parkinson’s diseases, multiple sclerosis or glaucoma defined as
ocular Alzheimer's disease, are associated with a large public health burden and are
among the leading causes of disability. Emerging evidences suggest that Hp-I may be
associated with neurodegenerative conditions. Moreover, Hp-I could be a predictor of
metabolic syndrome (MetS). Hp-I and its related MetS may induce gastrointestinal tract
dys-motility disorders with systemic complications possibly including central nervous
system neurodegenerative pathologies. We hereby explore the emerging role of Hprelated
metabolic gastrointestinal dys-motilities on the molecular pathophysiology of Hprelated
neurodegenerative and gastrointestinal disorders. Improving understanding of
such Hp-I pathophysiology in brain pathologies may offer benefits by application of new
relative therapeutic strategies including novel opportunities toward enhancing Hp
eradication.
