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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Medical Applications of Collagen and Collagen-Based Materials

Author(s): Anatoly B. Shekhter, Alexey L. Fayzullin*, Marina N. Vukolova, Tatyana G. Rudenko, Varvara D. Osipycheva and Petr F. Litvitsky

Volume 26, Issue 3, 2019

Page: [506 - 516] Pages: 11

DOI: 10.2174/0929867325666171205170339

Price: $65


Collagen and collagen-based materials have been successfully used in medicine for over 50 years. The number of scientific articles about the role of collagen in the construction of scaffolds for tissue engineering has risen precipitously in recent years. The review contains materials about historic and modern applications of collagen in medicine such as soluble collagen injections, solid constructs reconstructed from solution, and decellularized collagen matrices. The analysis of published data proves the efficacy of collagen material in the treatment of chronic wounds, burns, venous and diabetic ulcers, in plastic, reconstructive and general surgery, urology, proctology, gynecology, ophthalmology, otolaryngology, neurosurgery, dentistry, cardiovascular and bone and cartilage surgery, as well as in cosmetology. Further development of collagenoplasty requires addressing the problems of allergic complications, improvement of structure and maximizing therapeutic effects against pathological processes.

Keywords: Collagen, natural polymer, reconstructed collagen, decellularized collagen matrix, scaffold, tissue engineering.

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