Title:Microemulsion Systems: Prospective Approach for Superior Drug Delivery
Volume: 7
Issue: 3
Author(s): Karthikeyan Kesavan*, Nivedita Gautam, Shanni K. Bharti and Parasuraman Mohan
Affiliation:
- Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, (A Central University), Koni, Bilaspur, Chhattisgarh, 495009,India
Keywords:
Microemulsion, ocular, parentral, topical, SMEDDS, toxicity, stability.
Abstract: Background and Objective: Microemulsions (MEs) are thermodynamic stable dispersion of
oily phase and aqueous phase stabilized by surfactants, and frequently, with a combination of additives
or co-surfactants.
Discussion: This system may be either oil dispersed in water (O/W) or water dispersed in oil (W/O).
MEs are characteristically transparent solutions, as the globule size is about 100 nanometers or less.
MEs are impressive and prospective drug delivery systems due to their thermodynamic stability, enhanced
drug solubilisation, and effortlessness of development and administration. A proliferation of in
vitro and in vivo studies confirmed that drugs integrated into ME systems providing sustained release
and higher bioavailability. The enhancing bioavailability of the systems materializes due to a diversity
of factors depending on the components and the ensuing nanostructure.
Conclusion: This review is an effort to summarize the current development in the area of MEs, self
microemulsifying drug delivery system (SMEDDS) which are examined in relation to their application
in different route of administrations like ocular, parentral, and topical. The noteworthy patent, in vitro
and in vivo correlation related with these ME systems are also explored here.