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Current Alzheimer Research


ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Review Article

miRNAs in Alzheimer Disease – A Therapeutic Perspective

Author(s): Priya Gupta, Surajit Bhattacharjee, Ashish Ranjan Sharma, Garima Sharma, Sang-Soo Lee* and Chiranjib Chakraborty*

Volume 14, Issue 11, 2017

Page: [1198 - 1206] Pages: 9

DOI: 10.2174/1567205014666170829101016

Price: $65


Background: Alzheimer's disease is a neurodegenerative disorder which generally affects people who are more than 60 years of age. The disease is clinically characterised by dementia, loss of cognitive functions and massive neurodegeneration. The presence of neurofibrilary tangles and amyloid plaques in the hippocampal region of the brain are the hallmarks of the disease. Current therapeutic approaches for the treatment of Alzheimer's disease are symptomatic and disease modifying, none of which provide any permanent solution or cure for the disease. Dysregulation of miRNAs is one of the major causes of neurodegeneration.

Conclusion: In the present review, the roles of different miRNAs such as miR-9, miR-107, miR-29, miR-34, miR-181, miR-106, miR-146a, miR132, miR124a, miR153 has been discussed in detail in the pathogenesis of various neurodegenerative diseases with special focus on AD. The probability of miRNAs as an alternative and more sensitive approach for detection and management of the AD has also been discussed.

Keywords: Alzheimer's disease, neurodegeneration, miRNAs, therapeutics, dementia, neural plaques.

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