Abstract
The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs.
Keywords: Medicinal fungi, medicinal plants, anticancer, apoptosis, mitochondria.
Current Medicinal Chemistry
Title:Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants
Volume: 25 Issue: 40
Author(s): Jack Ho Wong*, Stephen Cho Wing Sze*, Tzi Bun Ng*, Randy Chi Fai Cheung, Chit Tam*, Kalin Yanbo Zhang*, Xiuli Dan, Yau Sang Chan, William Chi Shing Cho, Charlene Cheuk Wing Ng, Mary Miu Yee Waye, Weicheng Liang, Jinfang Zhang, Jie Yang, Xiuyun Ye, Juan Lin, Xiujuan Ye*, Hexiang Wang, Fang Liu, David Wai Chan*, Hextan Yuen Sheung Ngan*, Ou Sha*, Guohui Li, Ryan Tse, Tak Fu Tse*Helen Chan*
Affiliation:
- School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong,China
- School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong,China
- School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong,China
- School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong,China
- School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong,China
- Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, and Key Laboratory of Plant Virology of Fujian Province, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002,China
- Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong,China
- Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong,China
- Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen,China
- Vita Green Pharmaceuticals (HK) Ltd, Vita Green Health Products (HK) Ltd Genning Partners Company Limited, and Hong Kong Institute of Medical Research, Hong Kong,China
- Vita Green Pharmaceuticals (HK) Ltd, Vita Green Health Products (HK) Ltd Genning Partners Company Limited, and Hong Kong Institute of Medical Research, Hong Kong,China
Keywords: Medicinal fungi, medicinal plants, anticancer, apoptosis, mitochondria.
Abstract: The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs.
Export Options
About this article
Cite this article as:
Wong Ho Jack *, Sze Cho Wing Stephen *, Ng Bun Tzi*, Cheung Chi Fai Randy , Tam Chit *, Zhang Yanbo Kalin *, Dan Xiuli , Chan Sang Yau , Shing Cho Chi William , Ng Cheuk Wing Charlene , Waye Miu Yee Mary , Liang Weicheng , Zhang Jinfang , Yang Jie , Ye Xiuyun , Lin Juan , Ye Xiujuan *, Wang Hexiang , Liu Fang , Chan Wai David*, Ngan Yuen Sheung Hextan *, Sha Ou *, Li Guohui , Tse Ryan , Tse Fu Tak *, Chan Helen *, Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants, Current Medicinal Chemistry 2018; 25 (40) . https://dx.doi.org/10.2174/0929867324666170720165005
DOI https://dx.doi.org/10.2174/0929867324666170720165005 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Risk of Vertical HIV Transmission Combines the ‘B35-Cw4 Disadvantage’ and the ‘Pattern of Inheritance’ Theories of Progression
Current HIV Research Effect of an Angiotensin II Receptor Blocker and Two Angiotensin Converting Enzyme Inhibitors on Transforming Growth Factor-β (TGF-β) and α-Actomyosin (α SMA), Important Mediators of Radiation-Induced Pneumopathy and Lung Fibrosis
Current Pharmaceutical Design Adipocytokines; Cause for Metabolic Syndrome
Current Medicinal Chemistry - Central Nervous System Agents Antimutagenic, Antiproliferative and Antioxidant Properties of Sea Grape Leaf Extract Fractions (<i>Coccoloba uvifera</i> L.)
Anti-Cancer Agents in Medicinal Chemistry PET Imaging in Clinical Drug Abuse Research
Current Pharmaceutical Design The Signal Pathway of Antibiotic Alternatives on Intestinal Microbiota and Immune Function
Current Protein & Peptide Science Contemporary Review of Drugs Used to Treat Obesity
Cardiovascular & Hematological Agents in Medicinal Chemistry Profile of Secondary Bacterial Respiratory Infections in H1N1 Patients Admitted in a Tertiary Care Centre – A Four-year Retrospective Study
Infectious Disorders - Drug Targets Antimalarials in the Treatment of Schistosomiasis
Current Pharmaceutical Design Insight on the Body Fat Lowering Effect of 3,5-Diiodo-L-Thyronine
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Emerging Therapeutic Approaches Multi-Targeting Receptor Tyrosine Kinases and G Protein-Coupled Receptors in Cardiovascular Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Determination of Glimepiride in Pharmaceutical Formulations by Square-Wave Voltammetric Method
Current Analytical Chemistry Endless Pursuit: Evolution of Insulin Administration
Current Pharmaceutical Biotechnology Pharmacological Interactions of Paraoxonase 1 (PON1): A HDL-Bound Antiatherogenic Enzyme
Current Clinical Pharmacology Effects of Oral and Non-Insulin Injectable Antidiabetic Treatment in Hypertension: A Systematic Review
Current Pharmaceutical Design The Etiology of Hypertension in the Metabolic Syndrome Part Four: The Systemic Perspective – The Role of the Neuroendocrine and Immune Systems,and the Challenge of Integration
Current Vascular Pharmacology Donepezil May Reduce Insulin-Like Growth Factor-1 (IGF-1) Levels in Alzheimer’s disease
CNS & Neurological Disorders - Drug Targets Melanocortins and their Receptors and Antagonists
Current Drug Targets Potential Applications of Vasoactive Intestinal Peptide-Based Therapies on Transplantation
Endocrine, Metabolic & Immune Disorders - Drug Targets Use and Results of Antidepressant Treatment: Patients' Perception
Current Drug Therapy