Title:Review on Bioorganometallic Chemistry and New Outcomes in the Synthesis and Substitution of Tetracarbonyl(pyrrolylimine) Complexes of Rhenium with Organophosphorus Ligands
Volume: 17
Issue: 25
Author(s): Antoine Simonneau*, Franck Le Bideau*, Jean-Hugues Mirebeau, Jérôme Marrot and Gérard Jaouen
Affiliation:
- Laboratoire de Chimie de Coordination du CNRS, UPR 8241, 205 route de Narbonne, 31077 Toulouse cedex 4,France
- Department of BioCIS, Faculty of Pharmacy, University Université Paris-Saclay, 92290, Châtenay Malabry,France
Keywords:
Bioorganometallic Chemistry, Chirality, Octahedral complexes, Rhenium, Carbonyl complexes, Organophosphorus
ligands.
Abstract: After a short review dealing with bioorganometallic chemistry, the synthesis of tetracarbonyl(
pyrrolylimine) complexes of rhenium bearing chirality on the pyrrolyl ligands was reported.
The reactivity of these compounds towards the substitution of one carbonyl ligand with triphenyl
phosphine, tricyclohexyl phosphine and trimethyl phosphite was studied. The rhenium becoming a
stereogenic center in that transformation, the resulting tricarbonyl species were obtained as mixtures
of diastereomers, with diastereomeric excesses varying from 8 to 84%, according to the reaction conditions
and the relative steric hindrances of the pyrrolylimine and the organophosphorus ligands.
These bioorganometallics are potential CO releasing molecules that could be used in the field of medicinal
chemistry.
