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Current Radiopharmaceuticals


ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Research Article

Experiences with 99mTc-HMPAO in a Diagnostic Pathway for Violent Patients with Schizophrenic Spectrum Disorders

Author(s): Morten Jacobsen*, Arvid Jensen, Guttorm Breivik Storvestre, Tone Marie Bergstrom, Diyar Nori Mohamad Rashi, Bjorn Nielssen , Pal Wiktor and Knut-Erik Hymer

Volume 10, Issue 2, 2017

Page: [115 - 122] Pages: 8

DOI: 10.2174/1874471010666170621122221

open access plus


Background and Objective: In a security ward we assessed the diagnostic contribution of single photon scintigraphy [SPECT] in our diagnostic pathway for patients with serious mental disease and a history of violence.

Methods: Twenty patients were examined between 2012 and 2015 and the findings compared to those in nine patients with the same diagnosis, but no history of violence.

Results: All violent patients had areas with reduced accumulation of 99mTc-HMPAO frontally and in the temporal lobe, in the non-violent group only two patients demonstrated these findings.

Conclusion: Traditionally, low accumulation of the tracer in SPECT is related to reduced perfusion of brain tissue. We discuss our findings in the light of other possible pathophysiological mechanisms.

Keywords: SPECT, Schizophrenia spectrum disorder, brain perfusion, violence, forensic psychiatry.

Graphical Abstract

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