Generic placeholder image

Current Alzheimer Research


ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Review Article

PPARs in Neurodegenerative and Neuroinflammatory Pathways

Author(s): E. Benedetti, L. Cristiano, A. Antonosante, M. d'Angelo, B. d'Angelo, S. Selli, V. Castelli, R. Ippoliti, A. Giordano and A. Cimini*

Volume 15, Issue 4, 2018

Page: [336 - 344] Pages: 9

DOI: 10.2174/1567205014666170517150037

Price: $65


Background: PPARs are lipid sensors activated by dietary lipids or their metabolites, mainly fatty acids and eicosanoids, that play critical roles in CNS biology, since brain has a very high lipid content and has the higher energetic metabolism in the body.

Methods: In neurodegenerative diseases in addition to metabolic impairment, also neuroinflammation is observed and PPARs are also closely linked to inflammatory processes. Several studies have revealed a complicated relationship between the innate immune response and tissue metabolism.

Results: In the brain, during pathological conditions, an alteration in metabolic status occurs, particularly involving glucose utilization and production, a condition which is generally related to metabolic changes.

Conclusion: Taking into account the high expression of PPARs in the brain, this review will focus on the role of these transcription factors in CNS diseases.

Keywords: Neurodegenetic disease, immune system, microglia cells, cytokines, neuroinflammation, neurons.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy