Title:Recent Advances in Oncological Submissions of Dendrimer
Volume: 23
Issue: 21
Author(s): Namrata Soni, Muktika Tekade, Prashant Kesharwani, Pallab Bhattacharya, Rahul Maheshwari, Kamal Dua, Philp M. Hansbro and Rakesh Kumar Tekade*
Affiliation:
- National Institute of Pharmaceutical Education and Research (NIPER) – Ahmedabad, Palaj, Opposite Air Force Station, Gandhinagar, Gujarat-382355,India
Keywords:
Dendrimers, oncology, cancer therapy, cancer diagnosis, malignant tumor morphology, surgical resection.
Abstract: Background: Disseminated metastatic cancer requires insistent management owing to its reduced
responsiveness for chemotherapeutic agents, toxicity to normal cells consequently lower survival rate and hampered
quality of life of patients.
Methods: Dendrimer mediated cancer therapy is advantageous over conventional chemotherapy, radiotherapy and
surgical resection due to reduced systemic toxicity, and molecular level cell injury to cancerous mass, for an
appreciable survival of the subject. Recently used dendrimer mediated nanotechnology for oncology aims to
conquer these challenges. Dendrimers based nano-constructs are having architectures comparable to that of biological
vesicles present in the human body.
Results: Operating with dendrimer technology, proffers the exclusive and novel strategies with numerous applications
in cancer management involving diagnostics, therapeutics, imaging, and prognostics by sub-molecular interactions.
Dendrimers are designed to acquire the benefits of the malignant tumor morphology and characteristics,
i.e. leaky vasculature of tumor, expression of specific cell surface antigen, and rapid proliferation.
Conclusion: Dendrimers mediated targeted therapy recommends innovatory function equally in diagnostics (imaging,
immune-detection) as well as chemotherapy. Currently, dendrimers as nanomedicine has offered a strong
assurance and advancement in drastically varying approaches towards cancer imaging and treatment. The present
review discusses different approaches for cancer diagnosis and treatment such as, targeted and control therapy,
photodynamic therapy, photo-thermal therapy, gene therapy, antiangiogenics therapy, radiotherapy etc.
