Title:Cathepsin D as a Promising Target for the Discovery of Novel Anticancer Agents
Volume: 17
Issue: 5
Author(s): Vijaya Dubey and Suaib Luqman*
Affiliation:
- CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015, Uttar Pradesh,India
Keywords:
Aspartic protease, cancer, cathepsin D, chemoprevention, natural products, apoptosis.
Abstract: Background: Cathepsin D (CATD), one of the aspartyl endoproteinase involved in different
physiological processes and signaling pathways, is accountable for metabolic breakdown of
intracellular proteins, the activation of growth factors, hormones, and precursors of enzyme, the
processing of antigens, enzyme inhibitors and activators and the regulation of apoptosis.
Implication as a Target: Studies have confirmed the role and significance of CATD in an assortment
of pathological conditions like Atherosclerosis, Alzheimer, Cancer, Cardiovascular, Huntington
and Parkinson diseases. Amalgamated and veiled as inactive proCATD, it undergoes diverse
cleavages to attain a desired conformation in an acidic milieu to act as a functionally active protein.
In search of new candidate target (s) for cancer, CATD has attracted a wide group of investigators
across the globe and is being recognized as a well-defined marker in cancer especially for breast and
hormone-dependent cancer.
Methods: In this review, PubMed, Sci-finder and other search engines were used to gather information
on Cathepsin D. The necessary and relevant information was thoroughly studied to make the article
appropriate to highlight all the aspects related to Cathepsin D and its role in cancer.
Findings & Conclusion: The present review illustrates structural, functional and regulatory aspects
of CATD in cancer, its significant role in angiogenesis, metastasis, invasion, apoptosis, cell proliferation,
and therapeutic potential besides the benefits of targeting CATD by the natural products in
cancer chemoprevention.
