Title:Nanoparticle-mediated Drug Delivery Systems (DDS) in the Central Nervous System
Volume: 21
Issue: 3
Author(s): Guilong Zhang, Lukui Chen, Xiaoyuan Guo, Ahsan A. Khan, Yuchun Gu and Ning Gu
Affiliation:
Keywords:
Nanoparticle, drug delivery system, central nervous system, blood brain barrier.
Abstract: Recently, the development of nanotechnology and nanomaterial has promoted extremely the application
of drug delivery systems in the biomedical field. However, the drug delivery into the central nervous system
(CNS) is limited because the existence of the blood brain barrier (BBB). Therefore, to develop the efficient drug
delivery systems (DDS) for crossing the BBB into the lesions is necessary. The holistic DDS, which successfully
transfer drug into the brain, should be explored on the basis of biodegradable and non-cytotoxic nanomaterial. In
this review, we discussed the applications of nanoparticles-mediated DDS in the CNS and focused on the varied
nanocarrier strategies used for crossing the BBB and targeting the brain lesions, such as poly (PEG, PLA, and
PLGA) covalent-attached to nanoparticles strategies, lipid nanocarrier DDS strategy, polymeric/dendritic nanocarrier
DDS strategies, magnetic nanocarrier DDS strategy, and other (carbon nanotubes, viral, gold, silica etc.)
nanocarrier DDS strategies. In conclusion, the platform carrying nanoparticles-based drug vehicle is vital and
promising for developing the special brain drug delivery system. In future multifunctional nanocarriers may play
more important role in treating various neurological diseases.