Abstract
By the developmentof new antineoplastic drugs addressed tospecific sites (key to tumor growth), targeted agents, which do not interfere with most normal cells have many advantages like fewer side effects (as personalized treatment), and prolonged survival time of cancer patients compared to conventional therapy. As current approaches in cancer therapy, drug delivery systems based on polymers (synthetic, natural or combinations like micelles, nanospheres, nanocapsules, nanogels, polymer-drug conjugates, polymer-drug polyplex, polymersomes) are more benefic compared to parent free drug, because of targeted effect of delivery, low toxicity, solubility in biological fluids and immunostimulatory effects. Synthetic polymers (polyesters, polyamides and polyethers) are the most used core materials for drug delivery systems, many of them being officially certified. On the other hand due to their better biocompatibility and biodegradability, the natural ones (polysaccharides and proteins) are still a hot topic on cancer therapy as drug delivery and targeting materials. This article reviews the multifunctional materials used in targeting of drugs with polymer based delivery systems as current-day data and key of future applications on cancer therapy. An increasing interest in the last decades returns to the new, engineered inorganic materials as well as to the newly optimized composites and nanocomposites.
Keywords: Cancer, target therapeutics, drug delivery systems, polymers, inorganic materials, composites and nanocomposites.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
From Lab Bench to Algorithm: The Future of Organic Chemistry Powered by AI
Organic chemistry, with its intricate dance of molecules and reactions, is undergoing a transformation fuelled by the power of Artificial Intelligence (AI) and Machine Learning (ML). The integration of AI/ML with Organic Chemistry is revolutionizing the field by enhancing the efficiency and accuracy of chemical research and development. These technologies ...read more
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