Title:Therapeutic Antibodies for Spinal Cord Injury
Volume: 16
Issue: 1
Author(s): Dan-yang Tang and Wei-jiang Zhao
Affiliation:
Keywords:
Antibody, spinal cord injury, neuroprotective, myelin repair, anti-immune reaction, neuropathic pain
Abstract: Spinal cord injury (SCI) is a long-lasting damage in the spinal cord that leads to paraparesis,
paraplegia, quadriplegia and other lifetime disabilities. The underlying mechanisms responsible for the
failure of axonal regeneration after SCI remain only partially understood. Although a spectrum of
medical treatments has been made available for this disease, the therapeutic effects remain
disappointing. The emergence of antibody treatment has paved a new pathway for the management of
SCI. In this current review, we summarized the application of antibodies in SCI in studies of myelin
repair, neuroprotection, axon outgrowth, and anti-immune reaction. In the meantime, the combination
treatment of the antibody with other reagents or stem cell transplant was also reviewed.
