Title:The Role of NF-κB Inhibitors in Cell Response to Radiation
Volume: 23
Issue: 34
Author(s): Sajjad Molavi Pordanjani and Seyed Jalal Hosseinimehr
Affiliation:
Keywords:
Transcription factor, tumor, radiosensitizing, radioprotective, radiation, NF-κB inhibitors.
Abstract: It is well documented that ionizing radiation (IR) activates the
transcription factor (NF-κB) which is a trigger for resistance cancer cells to
treatment. It is involved in activation of pro-survival signaling pathways and
resulting in cancer development and progression. In unstimulated condition,
NF-κB is sequestered in cytoplasm but after the cell exposure to IR, proteasomal
degradation of IκB flowing phosphorylation via IKK, leads to aberrantly
NF-κB activation and nuclear translocation. Therefore, interruption in
IκB degradation, proteasome action, IKK phosphorylation and NF-κB nuclear
translocation provide robust strategies for inhibiting adverse effect of
IR induced NF-κB. In spite of uncompleted elucidation of NF-κB molecular
mechanisms, different NF-κB inhibitors have been used in order to inhibiting the IR induced
NF-κB. The aim of this review is to highlight the role of IR induced-NF-κB inhibitors such
as MG132, bortezomib, curcumin, DHMEQ, naringin, sorafenib, genistein and parthenolide
in suppression of IR induced NF-κB adverse effects. Moreover, their chemical, structural
characteristics and molecular mechanisms will be discussed.
