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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Review Article

Preclinical Evidence on the Anticancer Properties of Food Peptides

Author(s): Subin R.C.K. Rajendran, Chukwunonso E.C.C. Ejike, Min Gong, William Hannah and Chibuike C. Udenigwe

Volume 24, Issue 2, 2017

Page: [126 - 136] Pages: 11

DOI: 10.2174/0929866523666160816152755

Price: $65

Abstract

Natural, synthetic and analogues of peptides have shown prospects for application in cancer chemotherapy. Notably, some food protein-derived peptides are known to possess anticancer activities in cultured cancer cells, and also in animal cancer models via different mechanisms including induction of apoptosis, cell cycle arrest, cellular membrane disruption, inhibition of intracellular signalling, topoisomerases and proteases, and antiangiogenic activity. Although the mechanism of several anticancer food peptides is yet to be clearly elucidated, there is potential for practical applications of the peptides as functional food and nutraceutical ingredients, especially in adjuvant cancer therapy. This review describes the aetiological mechanisms of cancers and the production, structures, mechanisms of action, availability, and cellular and physiological anticancer activities of the food peptides.

Keywords: Bioactive peptides, anticancer, apoptosis, cancer, functional foods, nutraceuticals.

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