Title:Cytochrome P450 Drug Metabolizing Enzymes in Roma Population Samples: Systematic Review of the Literature
Volume: 23
Issue: 31
Author(s): Renata Szalai, Kinga Hadzsiev and Bela Melegh
Affiliation:
Keywords:
Polymorphisms, pharmacogenetics, Roma, Gypsy, Hungarian, interethnic, cytochrome P450.
Abstract: The cytochrome P450 drug metabolizing enzymes are highly polymorphic
and show inter-individual differences in variability in drug response,
which varies widely also with ethnicity. This study aims to summarize
the available data on genetic polymorphisms associated with cytochrome
enzymes conducted on Roma populations. Our goal was to compare the frequency
of the variant alleles, genotypes and predicted phenotypes with corresponding
rates from other populations. We carried out a systematic review
including the papers published on the pharmacogenetically relevant variants
of cytochrome P450 genes related to Roma population. The study was performed
using several articles, websites and databases, including PubMed,
Ensembl, dbSNP, HapMap and 1000 Genomes Project. This review attempts to summarize
and discuss our current knowledge about the frequency distribution of the ever investigated
20 allelic variants of 9 cytochrome genes (CYP1A2, CYP1B1, CYP2B6, CYP2C9, CYP2C19,
CYP2C8, CYP2D6, CYP3A5, CYP4F2) in Roma DNA samples and compare them with other
populations. Differences between Roma and Hungarian samples are reported for 7 variant
genotypes. CYP2C9 *2/*3 and CYP2C19 *2/*2 genotypes showed more than 3-fold differences.
Additional differences are displayed for allele frequency of 7 variants (rs762551,
rs3745274, rs1058930, rs1065852, rs3892097, rs1057910 and rs4244285) in Roma population
samples. The interethnic variability in clinically relevant genetic polymorphisms of drug
metabolizing enzymes, which may explain distinct drug response, highlights the need to allow
for the ancestry of participants in pharmacogenetic studies.
