Medicinal Attributes of Imidazo[1,2-a]pyridine Derivatives: An Update

Title:Medicinal Attributes of Imidazo[1,2-a]pyridine Derivatives: An Update

Volume: 16 Issue: 26

Author(s): Nisha Devi, Dharmender Singh, Ravindra K. Rawal, Jitender Bariwal and Virender Singh

Affiliation:

Keywords: Imidazo[1, 2-a]pyridine, SAR, Groebke-Blackburn-Bienayme reaction, Ugi Type, Multicomponent Reaction, N-fused imidazole.

Abstract: The imidazo[1,2-a]pyridine scaffold is recognized as a privileged structure as it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules. Several commercial drugs such as Zolpidem, Olprinone, Soraprazan and many other compounds in biological testing and preclinical evaluation, illustrate the wide therapeutic spectrum in this class of drug scaffolds. The present manuscript represents the assimilation of literature pertaining to medicinal aspects of this pharmacophore including the structure-activity relationships.

Cite this article as:

Devi Nisha, Singh Dharmender, Rawal K. Ravindra, Bariwal Jitender and Singh Virender, Medicinal Attributes of Imidazo[1,2-a]pyridine Derivatives: An Update, Current Topics in Medicinal Chemistry 2016; 16 (26) . https://dx.doi.org/10.2174/1568026616666160506145539