Title:Natural AMPK Activators: An Alternative Approach for the Treatment and Management of Metabolic Syndrome
Volume: 24
Issue: 10
Author(s): Hitender Sharma and Sunil Kumar*
Affiliation:
- Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana,India
Keywords:
Cardiovascular disorders, diabetes, obesity, metabolic syndrome, transcription factors, phytoconstituents.
Abstract: This review covers recent discoveries of phytoconstituents, herbal extracts and
some semi-synthetic compounds for treating metabolic syndrome with AMPK activation as
one of their mechanisms of action. Recent researches have demonstrated AMPK activation
to ameliorate multiple components of metabolic syndrome by regulating a balance between
anabolic and catabolic cellular reactions. The review attempts to delineate the AMPK activation
by natural agents from the perspective of its functional consequences on enzymes,
transcription factors and signaling molecules and also on other potential factors contributing
in the amelioration of metabolic syndrome.
