Title:Metabotropic Glutamate Receptors and Interacting Proteins in Epileptogenesis
Volume: 14
Issue: 5
Author(s): Feng Qian and Feng-Ru Tang
Affiliation:
Keywords:
Calmodulin, drug target, epileptogenesis, homer, interacting proteins, metabotropic glutamate receptors (mGluRs),
protein kinase C (PKC), signal transduction pathways.
Abstract: Neurotransmitter and receptor systems are involved in different neurological and
neuropsychological disorders such as Parkinson's disease, depression, Alzheimer’s disease and
epilepsy. Recent advances in studies of signal transduction pathways or interacting proteins of
neurotransmitter receptor systems suggest that different receptor systems may share the common
signal transduction pathways or interacting proteins which may be better therapeutic targets for
development of drugs to effectively control brain diseases. In this paper, we reviewed metabotropic glutamate receptors
(mGluRs) and their related signal transduction pathways or interacting proteins in status epilepticus and temporal lobe
epilepsy, and proposed some novel therapeutical drug targets for controlling epilepsy and epileptogenesis.
