Title:Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers
Volume: 22
Issue: 34
Author(s): Hamid Reza Mirzaei, Amirhossein Sahebkar, Mohsen Mohammadi, Reza Yari, Hossein Salehi, Mohammad Hasan Jafari, Afshin Namdar, Ehsan Khabazian, Mahmoud Reza Jaafari and Hamed Mirzaei
Affiliation:
Keywords:
Hepatocellular carcinoma, MicroRNA, diagnosis, prognosis, cancer.
Abstract: Hepatocellular carcinoma (HCC) is one of the most common types of malignancies
worldwide. There is little information on the mechanisms involved in the pathogenesis
of this disease. Diagnosis of HCC at early stages would be crucial for increasing the survival
of patients. Circulating miRNAs have emerged as one of the most attractive tools for an
early diagnosis of cancers. Various studies have shown that there is an aberrant expression
of miRNAs such as miR-25, miR-375, miR-206, miR-223, miR- 92a, miR-222, miR-1, let-
7f and miR-21 in HCC. Circulating and tissue miRNAs have also key roles in the pathogenesis
of HCC by affecting several biologically important pathways such as p53, p21,
PTEN, PI3K-AKT, c-Myc and STAT3. In this review, we summarize the current knowledge on the role of miRNAs
in diagnosis, prognosis, and treatment of HCC.
