Title:Potential of Unengineered and Engineered Wharton’s Jelly Mesenchymal Stem Cells as Cancer Inhibitor Agent
Volume: 15
Issue: 2
Author(s): Wahyu Widowati, Diana Krisanti Jasaputra, Sutiman B. Sumitro, M. Aris Widodo, Kelvin Yaprianto and Indra Bachtiar
Affiliation:
Keywords:
Cancer, cell free lyaste, conditioned medium, engineered mscs, mesenchymal stem cells, wharton’s jelly.
Abstract: Cancer is one the most common life-threatening diseases. Cancer cases worldwide are forecast
to rise by 75% in the future. Although cancer therapies have been improved, many tumors remain
unresponsive to conventional treatments, such as radiation and chemotherapy. Therefore, novel strategies
in treating and managing the disease are urgently needed. Wharton's Jelly-derived mesenchymal
stem cells (WJ-MSCs) have recently been shown to possess anti-cancer activities as well as tumor-homing ability. These
cells are able to migrate to sites of neoplastic growth in vivo and their secretory products display tumoricidal activity both
in vitro and in vivo models of human cancer. Recent reports also suggest that the anti-cancer potential of WJ-MSCs can
also be enhanced through genetic engineering. This review will summarize the current understanding on the interactions
between WJ-MSCs and tumor cells, as well as the potential use of both un-engineered and engineered WJ-MSCs as an
anti-cancer agent.
