Title:Targeting Interferon Regulatory Factor for Cardiometabolic Diseases: Opportunities and Challenges
Volume: 18
Issue: 15
Author(s): Yaxing Zhang, Xiao-Jing Zhang and Hongliang Li*
Affiliation:
- Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060,China
Keywords:
Interferon regulatory factor signaling, metabolic diseases, cardiac remodeling, vascular injury, stroke, vascular remodeling.
Abstract: Background: The pathological activation of innate immune system may contribute to the
development of cardiometabolic diseases. The interferon regulatory factor (IRF) family members,
which are the major transcription factors in innate immune signaling, are implicated in cardiometabolic
diseases.
Objective: The aim of this review is to summary the current knowledge of the biological functions of
IRFs in innate immune responses and immune cell development, and highlight our contemporary understanding
of the functions and molecular mechanisms of IRFs in metabolic diseases, cardiovascular
remodeling, and stroke.
Results: IRFs are the essential regulators of cardiometabolic diseases via immune-dependent and -
independent manners.
Conclusion: IRFs signaling is the promising target to manage the initiation and progression of cardiometabolic
disorders.
