Title:Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
Volume: 16
Issue: 9
Author(s): Pier M. Biava, Silvia Canaider, Federica Facchin, Eva Bianconi, Liza Ljungberg, Domenico Rotilio, Fabio Burigana and Carlo Ventura
Affiliation:
Keywords:
Stem cell differentiation stage factors, cancer stem cells, human adipose-derived stem cells, cell reprogramming,
cancer therapies, psoriasis, anti-aging treatments, neurodegeneration.
Abstract: In spite of the growing body of evidence on the biology of the Zebrafish embryo and stem cells, including the
use of Stem Cell Differentiation Stage Factors (SCDSFs) taken from Zebrafish embryo to impact cancer cell dynamics,
comparatively little is known about the possibility to use these factors to modulate the homeostasis of normal human stem
cells or to modulate the behavior of cells involved in different pathological conditions. In the present review we recall in a
synthetic way the most important researches about the use of SCDSFs in reprogramming cancer cells and in modulating
the high speed of multiplication of keratinocytes which is characteristic of some pathological diseases like psoriasis.
Moreover we add here the results about the capability of SCDSFs in modulating the homeostasis of human adiposederived
stem cells (hASCs) isolated from a fat tissue obtained with a novel-non enzymatic method and device. In addition
we report the data not yet published about a first protein analysis of the SCDSFs and about their role in a pathological
condition like neurodegeneration.
