Title:Left Ventricular 2-[18F]-Fluoro-2-Deoxy-D-Glucose Uptake Using Modified Oral Glucose Loading Protocol With Pre-Medicated Niacin On Positron Emission Tomography/Computed Tomography - A Preliminary Study
Volume: 3
Issue: 3
Author(s): Mohd Nazmi Nordin, Abdul Jalil Nordin, Fathinul Fikri Ahmad Saad and Hairil Rashmizal Abdul Razak
Affiliation:
Keywords:
Glucose uptake, myocardial viability, niacin, PET/CT.
Abstract: There are several protocols in the clinical assessment of myocardial viability using 18FFDG
PET/CT. This study assessed the intensity of 18F-FDG uptake in the wall of LV using a modified
protocol in one group (Group A) consisting of 11 volunteers compared with another group (Group B)
consisting of 11 patients who underwent 18F-FDG whole body (WB) PET/CT for oncology reasons.
The 18F-FDG uptake in the wall of LV was qualitatively and quantitatively assessed. The mean age for
group A and B were 35.00 ± 11.91 and 45.91 ± 14.58 respectively. The LV uptake of 18F-FDG was
significantly increased in Group A. There was a significant difference in mean SUVmax at basal (8.28
± 3.88 vs 3.79 ± 2.92, p=0.006), mid (5.32 ± 3.48 vs 3.71 ± 2.16, p=0.047), and apical (7.39 ± 3.57 vs 3.84 ± 2.82,
p=0.018) segments of LV. The mean normalized 18F-FDG distribution in 20-segment polar map expressed in percentage
for group B was lower in comparison to group A (61.02% vs 72.28%, p=0.034). Niacin can be utilized in combination
with glucose loading protocol to enhance glucose uptake using 18F-FDG PET/CT.
