Title:Biomaterial and Stem Cell Interactions: Histological Biocompatibility
Volume: 11
Issue: 6
Author(s): Petek Korkusuz, Sevil Kose and Cagla Zubeyde Kopru
Affiliation:
Keywords:
Biocompatibility, biomaterial, scaffold, stem cells, tissue engineering, tissue regeneration.
Abstract: Advancements in biomaterials and stem cell technology have lead current medical
technology to tissue engineering and regenerative medicine. Human engineered cartilage, bone, fascia,
tendon, nerve and skin tissues have been used for the treatment of tissue injuries and degenerative
diseases in combination with embryonic, fetal or adult stem and progenitor cells. Mesenchymal stem
cells are one of the most extensively studied adult stem cell population and are widely utilized in cell
therapies. Regeneration and 3-dimensional reconstruction of specialized connective tissues by combining differently
originated micro and nanoscaled, natural or synthetic scaffolds with stem or progenitor cells are highly expected to
guarantee patients to maintain acceptable life quality. In this review we discuss the important issues in biomaterial and
stem cell interactions based on histological biocompatibility, updating recent basic research in this field and addressing
possible future perspectives.
