Title:Novel Targets in Multiple Sclerosis: To Oxidative Stress and Beyond
Volume: 14
Issue: 22
Author(s): Valerio Chiurchiu
Affiliation:
Keywords:
Inflammation, Multiple sclerosis, Neurodegeneration, Oxidative stress, Remyelination, Therapeutics.
Abstract: Despite multiple sclerosis (MS) represents one of the most fascinating mystery of modern medicine
due to its unknown etiology and the incomplete knowledge of a clear mechanism of pathogenesis, progress
against this disease has made giant leaps. Current management of MS takes advantage of many disease-
modifying therapeutics of anti-inflammatory and immunomodulatory nature, whose primary aims are
halting immune responses during attacks, preventing new attacks and avoiding disability. In this review, a
synopsis on effective therapies targeting both immune-mediated responses and neurodegenerative processes
is appointed. Oxidative stress has been also implicated in both the inflammatory and neurodegenerative pathological
mechanisms underlying MS. The role of redox metabolism in MS is thus also reported, with particular focus on the latest
improvements in the identification of oxidative stress as a potential new therapeutic target.
