Title:New and Under Explored Epigenetic Modulators in Search of New Paradigms
Volume: 11
Issue: 3
Author(s): Mohammad Abrar Alam, Yeruva Suman Reddy and Mohamad Akbar Ali
Affiliation:
Keywords:
Aging, epigenetics, cancer, diabetes, gene, and histone.
Abstract: Aberrant regulation of epigenetic pathways causes many diseases including aging, cancer,
diabetes, viral pathogenesis, drug addiction etc. and it has been estimated that epigenetic aberrations
are at least ten to forty times more frequent in cancers than genetic mutations. Present epigenetic
modulators hold great promise for a variety of diseases, and important tools for biological applications
but these molecules have many dose limiting toxicities and existing paradigms lack desired efficacy.
Synthesis and biological studies of epigenetic modulators have been attractive targets for medicinal
and synthetic organic chemists in recent years. This review article provides deep insight into the new
and under explored epigenetic modulators. These molecules have the potential to be used as unique template with novel
pharmacophores.
