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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Occurrence and Biological Activities of Eremophilane-type Sesquiterpenes

Author(s): Chenjie Hou, Marianna Kulka, Junzeng Zhang, Yiming Li and Fujiang Guo

Volume 14, Issue 8, 2014

Page: [664 - 677] Pages: 14

DOI: 10.2174/1389557514666140820105422

Price: $65


As important members of the terpenes family, sesquiterpenes represent a group of natural compounds with diverse skeletal types. Among them, the eremophilane-type sesquiterpenes, widely present in several genera (such as Ligularia, Senecio, Cacalia) of Asteraceae, account for a small number of natural compounds and form differently from other sesquiterpenes because they challenged the isoprene rule of biosynthesis. Due to the unique structural features and various functional groups, these compounds possess a number of biological activities such as anti-tumor, anti-bacterial and anti-inflammatory, having received increasing interest in the recent years. This review summarizes the occurrence of eremophilane-type sesquiterpenes and research progresses on their biological activities since the 1990s.

Keywords: Anti-tumor, anti-microbial, anti-inflammatory, anti-allergy, eremophilane-type sesquiterpenes.

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