Title:Phytoestrogens and Mitochondrial Biogenesis in Breast Cancer. Influence of Estrogen Receptors Ratio
Volume: 20
Issue: 35
Author(s): Pilar Roca, Jorge Sastre-Serra, Mercedes Nadal-Serrano, Daniel Gabriel Pons, Ma del Mar Blanquer-Rossello and Jordi Oliver
Affiliation:
Keywords:
Phytoestrogens, breast cancer, energy metabolism, oxidative stress, ERalpha/ERbeta.
Abstract: Phytoestrogens were originally identified as compounds having a close similarity in structure to estrogens and harboring weak
estrogen activity. The interest in phytoestrogens as potential therapeutic agents has recently risen in the field of oncology, since population
based studies have linked phytoestrogens consumption with a decreased risk of mortality due to several types of cancer. This review
departs from the main focus of these articles by describing recent advances in our understanding of phytoestrogen potential action on mitochondria,
specifically on mitochondrial biogenesis, dynamics and functionality, as well as mitoptosis in breast cancer. Further studies
are necessary to explain the effects of individual phytoestrogens on mitochondrial biogenesis and dynamics and for designing of new
therapy targets for cancer treatment, nevertheless area promising therapeutic approach.
