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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Synaptic Dysfunction in Synucleinopathies

Author(s): Oleg Anichtchik, Laura Calo and Maria Grazia Spillantini

Volume 12, Issue 8, 2013

Page: [1094 - 1100] Pages: 7

DOI: 10.2174/18715273113129990114

Price: $65


Pathological aggregation of alpha-synuclein as Lewy-bodies and neurites is a hallmark of a group of neurodegenerative disorders named alpha-synucleinopathies. It is becoming apparent that alpha-synuclein facilitates presynaptic neuronal function in the brain, and events leading to its aggregation produce marked disruption of neurotransmitter release mechanism. We discuss here the literature related to the function of alpha-synuclein at the neuronal synapse in synucleinopathies brains and corresponding animal models.

Keywords: Synaptic dysfunction, synucleinopathies, neurodegenerative disorders, animal models, Alzheimer’s disease, central nervous system, dementia, Lewy body.

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