Title:Medicinal Chemistry of Antimigraine Drugs
Volume: 20
Issue: 26
Author(s): K. Tekes, P. Szegi, F. Hashemi, R. Laufer, H. Kalasz, A. Siddiq and C. Ertsey
Affiliation:
Keywords:
Migraine treatment, pharmacodynamics, pharmacokinetics.
Abstract: Migraine is one of the most frequent neurological disorder with high impact on the quality of life. Primary
headaches such as migraine are pathophysiologically complex disorders. The concept of the trigeminovascular system
dysfunction in migraine has led to a number of drug discoveries dramatically changing the treatment options. Acute and
prophylactic therapy targeting either the trigeminovascular system or central structures involve several groups of drugs
with peculiar medicinal chemistry. In the proposed review up to date concept of treatment strategy, medicinal chemistry
data of the drugs used will be summarized. The present review gives detailed information on drugs effective in aborting
migraine attacks (by inhibiting prostanoid synthesis, are agonists of serotonin 5-HT1B/D receptors, on the recently introduced
CGRP-receptor antagonists) and the drugs recommended for prophylactic treatment (selected beta-adrenergic receptor
antagonists, Ca-channel inhibitors, antiepileptics, antidepressants). The pharmacokinetics, fate in the body (absorption,
distribution, metabolism, excretion) and significant pharmacological effects as well as the recent bioanalytical methods
for their determination are presented.
