Title:An Overview of Valuable Scientific Models for Diabetes Mellitus
Volume: 9
Issue: 4
Author(s): Muhammad Sajid Hamid Akash, Kanwal Rehman and Shuqing Chen
Affiliation:
Keywords:
Biomarkers, biosensors, Diabetic animal models, High throughput screening, oxidative stress, nonmaterials in diabetes,
metabolic fingerprinting, glucolipotoxicity.
Abstract: Diabetes mellitus is one of the major clinical problems worldwide. Previously, most of the investigational studies
for identification of disease and new therapies were based on animal studies; however, present research methods involve
high throughput screening, molecular targeting, nanotechnology for recent discovery of drugs and disease identification
to combat against hazardous diseases like diabetes mellitus. In this review, we have depicted outlines enfolding
various disease-specific animal modeling, sensing technologies, biomarker analysis, and novel scientific techniques that
could be helpful in exploring the impending strategies for diabetes detection and treatment. To conclude, we believe that
endorsement and upgrading of such novel high throughput screening assays and nanotechnology described herein may
surely represent a significant improvement in the capability for screening and identifying the population at elevated risk of
expected diabetes. Thereby in future, appreciation of such investigational techniques and technologies including metabolomics
and genetic screening may help in early prediction of diabetes in patients at risk and may display a significant
improvement over the researchers conducted after the declaration of the disease.
